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Gene Information
Gene symbol: PTHR1
Gene name: parathyroid hormone receptor 1
HGNC ID: 9608
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PTH | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8769838 | Localization of parathyroid hormone/parathyroid hormone-related peptide receptor mRNA in kidney. |
| 2 | 8769838 | To define cells expressing receptors for PTH in kidney, we localized PTH/ PTH-related peptide (PTH/PTHrP) receptor mRNA in rat kidney by in situ hybridization. |
| 3 | 8769838 | PTH/PTHrP receptor mRNA is localized to glomerular podocytes, convoluted and straight proximal tubules, the cortical portion of thick ascending limbs, and distal convoluted tubules, but was not detected in the thin limb of Henle's loop or in collecting ducts. |
| 4 | 8769838 | Northern blot analysis showed that cultured human glomerular podocytes express a unique 4.0-kb PTH/PTHrP receptor transcript but do not express detectable levels of the common approximately 2.4-kb transcript found in whole kidney and in many other tissues. |
| 5 | 8769838 | Whereas the tubular localization of PTH/PTHrP receptor mRNA coincides well with previously known sites of PTH action, the intense expression and the unique size of the PTH/PTHrP receptor transcript in glomerular podocytes suggest that PTH and/or PTHrP may play a role(s) in glomerular function. |
| 6 | 8977437 | The kidney is the major site of expression of the PTH/PTH-related peptide receptor (PTHR) gene. |
| 7 | 8977437 | Immunohistochemical and immunoelectron microscopic analysis showed that PTHR protein is expressed on both basolateral and luminal membranes of proximal tubular epithelial cells, strongly suggesting a bipolar mode of action of PTH. |
| 8 | 8977437 | The kidney is the major site of expression of the PTH/PTH-related peptide receptor (PTHR) gene. |
| 9 | 8977437 | Immunohistochemical and immunoelectron microscopic analysis showed that PTHR protein is expressed on both basolateral and luminal membranes of proximal tubular epithelial cells, strongly suggesting a bipolar mode of action of PTH. |
| 10 | 9121603 | The first receptor which has been cloned and well characterized is "PTH/PTHrP receptor-1". |
| 11 | 9121603 | It is activated not only by PTH, but also by PTH-related peptide (PTHrP), via a signal transduction system involving G-proteins, adenylate cyclase and phospholipase C. |
| 12 | 9121603 | One or several receptors are probably expressed in the keratinocyte and the glomerular podocyte which are not identical with PTH/ PTHrP receptor-1. |
| 13 | 9121603 | A third receptor, which has been cloned recently and called "PTH2 receptor", recognizes solely PTH. |
| 14 | 9121603 | There is also evidence for a fourth receptor, called "C-PTH receptor", recognizing C-terminal PTH fragments which are generally considered to be biologically inactive. |
| 15 | 9121603 | Down-regulation of PTH/PTHrP receptor-1 mRNA expression could explain the well-known resistance to the action of PTH in chronic renal failure. |
| 16 | 9121603 | A mutation of PTH/PTHrP receptor-1 causes Jansen-type metaphyseal chondrodysplasia. |
| 17 | 9121603 | However, no alteration of the PTH/PTHrP receptor-1 gene structure has been found in type 1b pseudohypoparathyroidism. |