- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: TP53
Gene name: tumor protein p53
HGNC ID: 11998
Synonyms: p53, LFS1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDKN1A | 1 hits |
| 2 | WT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9108440 | Induction of p21 by the Wilms' tumor suppressor gene WT1. |
| 2 | 9108440 | We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with transcriptional repression of the endogenous epidermal growth factor receptor. |
| 3 | 9108440 | We now show that WT1-mediated apoptosis is preceded by induction of the cyclin-dependent kinase inhibitor p21, associated with G1 phase arrest. |
| 4 | 9108440 | This effect is only demonstrated by WT1 isoforms with an intact DNA binding domain, and it is associated with increased expression of endogenous p21 mRNA. |
| 5 | 9108440 | WT1-mediated induction of p21 is independent of p53, another tumor suppressor gene known to regulate p21 expression. |
| 6 | 9108440 | In the kidney, p21 is expressed in differentiating glomerular podocytes along with WT1. |
| 7 | 9108440 | We conclude that induction of p21 expression may contribute to WT1-dependent differentiation pathways in the kidney and potentially to the function of WT1 as a tumor suppressor gene. |