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Gene Information
Gene symbol: VCL
Gene name: vinculin
HGNC ID: 12665
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCAR1 | 1 hits |
| 2 | CDH3 | 1 hits |
| 3 | PTK2 | 1 hits |
| 4 | PXN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8074995 | However, P-cadherin, plakoglobin and vinculin are the only markers detected in future glomerular cells. |
| 2 | 9422981 | The cytoplasmic focal adhesion proteins vinculin, talin, paxillin, p130CAS, and pp125FAK were detected, although vinculin appeared to be confined mainly to the mesangium. |
| 3 | 11553524 | CD2AP and p130Cas localize to different F-actin structures in podocytes. |
| 4 | 11553524 | Mice lacking the 80-kDa CD2-associated protein (CD2AP) develop progressive renal failure that starts soon after birth with proteinuria and foot process effacement by unknown mechanisms. |
| 5 | 11553524 | CD2AP has been identified and cloned independently by virtue of its interaction with the T cell protein CD2 and with the docking protein p130Cas. |
| 6 | 11553524 | In the present study we examined the localization of CD2AP and p130Cas in the mouse glomerulus and in cultured podocytes. |
| 7 | 11553524 | In glomeruli, CD2AP and p130Cas immunofluorescence were observed in podocytes, where they colocalized with F-actin in foot processes. |
| 8 | 11553524 | In cultured podocytes, p130Cas was enriched at sites of focal adhesions, where it colocalized like vinculin with F-actin at stress fiber ends. |
| 9 | 11553524 | The spot-shaped F-actin structures were also stained by antibodies against the actin nucleation Arp2/3 complex and cortactin, both contributing to dynamic actin assembly. |
| 10 | 11553524 | Moreover, CD2AP spots in cultured podocytes were in close spatial association with actinin-4, but not actinin-1. |
| 11 | 11553524 | Our results suggest that CD2AP and p130Cas, which both colocalize with F-actin in podocytes in situ, possess different functions. |
| 12 | 11553524 | Whereas p130Cas is found in focal adhesions, CD2AP seems to be involved in the regulation of highly dynamic F-actin structures in podocyte foot processes. |