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Gene Information
Gene symbol: VWF
Gene name: von Willebrand factor
HGNC ID: 12726
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDH17 | 1 hits |
| 2 | KDR | 1 hits |
| 3 | THY1 | 1 hits |
| 4 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9621286 | The ability of VEGF to be chemotactic for monocytes and to increase the activity of collagenase and plasminogen activator may have implications for renal development and renal disease. |
| 2 | 9621286 | In humans, the cellular actions of VEGF depend on binding to two specific receptors: Flt-1 and KDR. |
| 3 | 9621286 | The aims of this study were: (1) to localize VEGF receptor proteins in human renal ontogenesis; (2) to quantify VEGF binding in human fetal and adult kidney; and (3) to dissect the binding into its two known components: the KDR and Flt-1 receptors. |
| 4 | 9621286 | The latter aim was achieved by competitive binding of VEGF and placenta growth factor-2, which only binds to Flt-1. |
| 5 | 9621286 | By double-label immunohistochemistry, VEGF receptor proteins were localized solely to endothelial cells of preglomerular vessels, glomeruli, and postglomerular vessels. |
| 6 | 9621286 | In developing glomeruli, VEGF receptor protein appeared as soon as endothelial cells were positive for von Willebrand factor. |
| 7 | 9621286 | Placenta growth factor-2 displaced VEGF binding in all renal structures by approximately 60%. |
| 8 | 9621286 | VEGF receptor proteins thus were found only in renal endothelial cells. |
| 9 | 9621286 | A coexpression of both VEGF binding sites could be shown, with Flt-1 demonstrating the most abundant VEGF receptor binding sites in the kidney. |
| 10 | 11456410 | The arborized cells from decapsulated glomeruli showed intense staining for a podocyte-specific marker, podocalyxin, but no staining for markers specific to PECs (pan cadherin), mesangial cells (Thy-1) or endothelial cells (von Willebrand factor, RECA-1), indicating their podocyte origin. |
| 11 | 11456410 | Thus, the cell population from decapsulated glomeruli is distinctly different from that from encapsulated glomeruli, supporting the idea that polygonal cells originate from PECs, although immunocytochemical markers specific to podocytes in vivo such as WT1, synaptopodin, HSP27 and P-31 antigen were expressed significantly in the polygonal cells. |