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Gene Information
Gene symbol: ABRA
Gene name: actin-binding Rho activating protein
HGNC ID: 30655
Synonyms: STARS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | MKL1 | 1 hits |
| 4 | RHOD | 1 hits |
| 5 | SRF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21393865 | Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. |
| 2 | 21393865 | Actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator megakaryoblastic leukemia 1 (MKL1) had increased expression in T2D and FH(+) groups. |
| 3 | 21393865 | Furthermore, striated muscle activator of Rho signaling (STARS), an activator of SRF, was upregulated in T2D and FH(+) and was inversely correlated with insulin sensitivity. |
| 4 | 21393865 | Skeletal muscle from insulin-resistant mice recapitulated this gene expression pattern and showed reduced G-actin and increased nuclear localization of MKL1, each of which regulates SRF activity. |
| 5 | 21393865 | Overexpression of MKL1 or reduction in G-actin decreased insulin-stimulated Akt phosphorylation, whereas reduction of STARS expression increased insulin signaling and glucose uptake. |
| 6 | 21393865 | Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo. |
| 7 | 21393865 | Thus, SRF pathway alterations are linked to insulin resistance, may contribute to T2D pathogenesis, and could represent therapeutic targets. |
| 8 | 21393865 | Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. |
| 9 | 21393865 | Actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator megakaryoblastic leukemia 1 (MKL1) had increased expression in T2D and FH(+) groups. |
| 10 | 21393865 | Furthermore, striated muscle activator of Rho signaling (STARS), an activator of SRF, was upregulated in T2D and FH(+) and was inversely correlated with insulin sensitivity. |
| 11 | 21393865 | Skeletal muscle from insulin-resistant mice recapitulated this gene expression pattern and showed reduced G-actin and increased nuclear localization of MKL1, each of which regulates SRF activity. |
| 12 | 21393865 | Overexpression of MKL1 or reduction in G-actin decreased insulin-stimulated Akt phosphorylation, whereas reduction of STARS expression increased insulin signaling and glucose uptake. |
| 13 | 21393865 | Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo. |
| 14 | 21393865 | Thus, SRF pathway alterations are linked to insulin resistance, may contribute to T2D pathogenesis, and could represent therapeutic targets. |