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Gene Information
Gene symbol: ACAA2
Gene name: acetyl-CoA acyltransferase 2
HGNC ID: 83
Synonyms: DSAEC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACAA1 | 1 hits |
| 2 | CPT1A | 1 hits |
| 3 | HADH | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17491019 | This study examines HADHSC expression in purified rat beta cells and investigates whether its selective suppression elevates insulin release. |
| 2 | 17491019 | On the other hand, beta cells expressed relatively low levels of other beta-oxidation enzymes (acyl-CoA dehydrogenase short, medium, and long chain and acetyl-coenzyme A acyltransferase 2). |
| 3 | 17491019 | HADHSC expression was sequence-specifically silenced by RNA interference, and the effects were examined on glucose-stimulated insulin secretion following 48-72 h of suppression. |
| 4 | 17491019 | In both rat beta cells and in the beta cell line INS1 832-13, HADHSC silencing resulted in elevated insulin release at low and at high glucose concentrations, which appeared not to be caused by increased rates of glucose metabolism or an inhibition in fatty acid oxidation. |
| 5 | 17491019 | Down-regulation of HADHSC causes an elevated secretory activity suggesting that this enzyme protects against inappropriately high insulin levels and hypoglycemia. |
| 6 | 23842279 | In the presence of PPARβ/δ, Vpr induced a 3.3-fold increase in PPAR response element-driven transcriptional activity, a 1.9-fold increase in pyruvate dehydrogenase kinase 4 (PDK4) protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase subunit E1α leading to a 47% decrease in the activity of the pyruvate dehydrogenase complex in HepG2 cells. |
| 7 | 23842279 | Vpr induced a 1.3-fold increase in mRNA expression of both carnitine palmitoyltransferase I (CPT1) and acetyl-coenzyme A acyltransferase 2 (ACAA2) and doubled the activity of β-hydroxylacyl coenzyme A dehydrogenase (HADH). |
| 8 | 23842279 | The effects of Vpr on PPAR response element activation, pyruvate dehydrogenase complex activity, and β-oxidation were reversed by specific PPARβ/δ antagonists. |