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Gene Information
Gene symbol: ACCN2
Gene name: amiloride-sensitive cation channel 2, neuronal
HGNC ID: 100
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACCN1 | 1 hits |
| 2 | ACCN3 | 1 hits |
| 3 | BSND | 1 hits |
| 4 | CFTR | 1 hits |
| 5 | CLCN2 | 1 hits |
| 6 | GRIK2 | 1 hits |
| 7 | KCNA3 | 1 hits |
| 8 | KCNA5 | 1 hits |
| 9 | KCND3 | 1 hits |
| 10 | KCNE1 | 1 hits |
| 11 | KCNJ1 | 1 hits |
| 12 | KCNQ1 | 1 hits |
| 13 | KCNQ4 | 1 hits |
| 14 | SCN5A | 1 hits |
| 15 | SGK1 | 1 hits |
| 16 | TRPV1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20190512 | [Activation and regulation of nociceptive transient receptor potential (TRP) channels, TRPV1 and TRPA1]. |
| 2 | 20190512 | Mechanisms for the detection of alkaline pH by sensory neurons are not well understood, although it is well accepted that acidic pH monitoring can be attributed to several ion channels, including TRPV1 and ASICs. |
| 3 | 23012321 | SGK1 is activated by insulin and growth factors through PI3K and 3-phosphoinositide-dependent kinase PDK1. |
| 4 | 23012321 | SGK1 activates a wide variety of ion channels (e.g., ENaC, SCN5A, TRPV4-6, ROMK, Kv1.3, Kv1.5, Kv4.3, KCNE1/KCNQ1, KCNQ4, ASIC1, GluR6, ClCKa/barttin, ClC2, CFTR, and Orai/STIM), which participate in the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation, and apoptosis. |
| 5 | 23723009 | Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation. |
| 6 | 23723009 | Immunofluorescence indicates opposite regulation of different ASIC transcripts while qRT-PCR shows that ASIC mRNA ranking (ASIC2 > ASIC1 > ASIC3) remains unaltered. |
| 7 | 23723009 | Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation. |
| 8 | 23723009 | Immunofluorescence indicates opposite regulation of different ASIC transcripts while qRT-PCR shows that ASIC mRNA ranking (ASIC2 > ASIC1 > ASIC3) remains unaltered. |