Ignet

Gene Information

Gene symbol: ACCN3

Gene name: amiloride-sensitive cation channel 3

HGNC ID: 101

Related Genes

#	Gene Symbol	Number of hits
1	ACCN1	1 hits
2	ACCN2	1 hits
3	AKT1	1 hits
4	INS	1 hits

Related Sentences

#	PMID	Sentence
1	18466760	Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.
2	18466760	ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity.
3	18466760	Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice.
4	18466760	Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues.
5	18466760	Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.
6	18466760	Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.
7	18466760	ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity.
8	18466760	Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice.
9	18466760	Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues.
10	18466760	Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.
11	18466760	Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.
12	18466760	ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity.
13	18466760	Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice.
14	18466760	Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues.
15	18466760	Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.
16	18466760	Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.
17	18466760	ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity.
18	18466760	Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice.
19	18466760	Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues.
20	18466760	Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.
21	18466760	Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.
22	18466760	ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity.
23	18466760	Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice.
24	18466760	Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues.
25	18466760	Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.
26	23723009	Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation.
27	23723009	Immunofluorescence indicates opposite regulation of different ASIC transcripts while qRT-PCR shows that ASIC mRNA ranking (ASIC2 > ASIC1 > ASIC3) remains unaltered.