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Gene Information
Gene symbol: ACMSD
Gene name: aminocarboxymuconate semialdehyde decarboxylase
HGNC ID: 19288
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HAAO | 1 hits |
| 2 | INDO | 1 hits |
| 3 | INS | 1 hits |
| 4 | KMO | 1 hits |
| 5 | KYNU | 1 hits |
| 6 | PARP1 | 1 hits |
| 7 | RAB3GAP1 | 1 hits |
| 8 | TDO2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1294473 | Administration of sodium orthovanadate (0.3 mg/ml) through drinking water for 20 days to streptozotocin-induced diabetic rats resulted in reversal of markedly elevated activities of some of the key enzymes of tryptophan-niacin pathway, viz. hepatic and renal aminocarboxymuconate semialdehyde decarboxylase and hepatic tryptophan oxygenase, to normal levels without restoring the elevated blood sugar level to normal state. |
| 2 | 7671148 | In the diabetic+insulin group, hepatic ACMSD activity was significantly lower than in the diabetic group. |
| 3 | 9362115 | We investigated the effects of feeding with a diet containing pyrazinamide (PYR) on the metabolism of L-tryptophan (Trp) to nicotinamide in streptozotocin (STZ)-diabetic rats and whether the diabetic action of STZ is prevented by feeding with the PYR diet, which is known as an inhibitor of aminocarboxymuconate-semialdehyde decarboxylase and poly(ADP)ribose synthetase and therefore, significantly increases the formation of nicotinamide from Trp in normal rats. |
| 4 | 12031285 | The enzymes assayed were: liver tryptophan 2,3-dioxygenase (TDO), intestine indoleamine 2,3-dioxygenase (IDO), liver and kidney kynurenine 3-monooxygenase, kynurenine-oxoglutarate transaminase, kynureninase, 3-hydroxyanthranilate 3,4-dioxygenase and aminocarboxymuconate-semialdehyde decarboxylase.TDO showed a reduction of specific activity in liver of diabetic-hyperlipidemic and hyperlipidemic rabbits compared to controls. |
| 5 | 12042425 | Insulin administration (2 U/12 h) reduced the elevated ACMSD activity and fully suppressed the elevated ACMSD mRNA expression due to STZ injection. |
| 6 | 23209189 | TMEM163 variants also showed association with decreased fasting plasma insulin and homeostatic model assessment of insulin resistance, indicating a plausible effect through impaired insulin secretion. |
| 7 | 23209189 | The 2q21 region also harbors RAB3GAP1 and ACMSD; those are involved in neurologic disorders. |