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Gene Information
Gene symbol: ACVR1C
Gene name: activin A receptor, type IC
HGNC ID: 18123
Synonyms: ALK7, ACVRLK7
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACVR1B | 1 hits |
| 2 | DICER1 | 1 hits |
| 3 | INHBE | 1 hits |
| 4 | INS | 1 hits |
| 5 | NR6A1 | 1 hits |
| 6 | PDX1 | 1 hits |
| 7 | SMAD2 | 1 hits |
| 8 | SMAD3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18951876 | Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells. |
| 2 | 18951876 | In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. |
| 3 | 18951876 | Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. |
| 4 | 18951876 | These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway. |
| 5 | 18951876 | Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells. |
| 6 | 18951876 | In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. |
| 7 | 18951876 | Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. |
| 8 | 18951876 | These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway. |
| 9 | 21353873 | A type I receptor, which is a component of the complex, is known as an activin receptor-like kinase (ALK); currently seven ALKs (ALK1-ALK7) have been identified in humans. |
| 10 | 21353873 | Activins signaling, which is mediated by ALK4 and 7 together with ActRIIA and IIB, plays a critical role in glucose-stimulated insulin secretion, development/neogenesis, and glucose homeostatic control of pancreatic endocrine cells; the insulin gene is regulated by these signaling pathways via ALK7, which is a receptor for Activins AB and B and Nodal. |
| 11 | 23518926 | Further study of Dicer-KO adrenals demonstrated a significant loss of steroidogenic factor 1-expressing cortical cells that was histologically evident as early as E16.5 coincident with an increase in p21 and cleaved-caspase 3 staining in the cortex. |
| 12 | 23518926 | Consistent with the absence of Dicer and the associated loss of miRNA-mediated mRNA degradation, we observed an up-regulation of a small subset of adrenal transcripts in Dicer-KO mice, most notably the transcripts coded by the genes Nr6a1 and Acvr1c. |
| 13 | 23518926 | Indeed, several miRNAs, including let-7, miR-34c, and miR-21, that are predicted to target these genes for degradation, were also markedly down-regulated in Dicer-KO adrenals. |