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Gene Information
Gene symbol: ACVR2B
Gene name: activin A receptor, type IIB
HGNC ID: 174
Synonyms: ActR-IIB
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACVR2A | 1 hits |
| 2 | FST | 1 hits |
| 3 | INHBE | 1 hits |
| 4 | MSTN | 1 hits |
| 5 | SNX6 | 1 hits |
| 6 | TGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11279102 | Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |
| 2 | 11279102 | Human SNX1, -2, and -4 have been proposed to play a role in receptor trafficking and have been shown to bind to several receptor tyrosine kinases, including receptors for epidermal growth factor, platelet-derived growth factor, and insulin as well as the long form of the leptin receptor, a glycoprotein 130-associated receptor. |
| 3 | 11279102 | We now describe a novel member of this family, SNX6, which interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. |
| 4 | 11279102 | Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. |
| 5 | 11279102 | Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. |
| 6 | 11334431 | No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. |
| 7 | 11334431 | For transmembrane signaling, activins bind directly to activin receptor type 2A (ACVR2A) or 2B (ACVR2B). |
| 8 | 11334431 | No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. |
| 9 | 11334431 | For transmembrane signaling, activins bind directly to activin receptor type 2A (ACVR2A) or 2B (ACVR2B). |
| 10 | 15180456 | Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. |
| 11 | 15180456 | Recent studies have revealed that activins and myostatin signal through activin type II receptors (ActRIIA and ActRIIB) and their activities are regulated by extracellular binding proteins, follistatins and follistatin-related gene (FLRG). |
| 12 | 21353874 | Activin receptor type IIB (ActRIIB) belongs to a type II transforming growth factor-β (TGF-β) serine/threonine kinase receptor family which is integral to the activin and myostatin signaling pathway. |
| 13 | 21353874 | Actvin and myostatin bind to activin type II receptors (ActRIIA and ActRIIB), and the glycine-serine-rich domains of type I receptors are phosphorylated by type II receptors. |
| 14 | 21353874 | Activin receptor type IIB (ActRIIB) belongs to a type II transforming growth factor-β (TGF-β) serine/threonine kinase receptor family which is integral to the activin and myostatin signaling pathway. |
| 15 | 21353874 | Actvin and myostatin bind to activin type II receptors (ActRIIA and ActRIIB), and the glycine-serine-rich domains of type I receptors are phosphorylated by type II receptors. |