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Gene Information
Gene symbol: ADAM12
Gene name: ADAM metallopeptidase domain 12
HGNC ID: 190
Synonyms: MCMPMltna, MLTN
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IGFBP4 | 1 hits |
| 2 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23319319 | We have examined the progression and regulation of myogenesis, cellular levels of IGFBP-4, -5, -6, and several extracellular matrix (ECM) proteins (fibronectin, integrin α5, β1 subunits and a disintegrin metalloprotease ADAM12) in murine C2C12 myoblasts during 3-day differentiation under high glucose alone or combined with high insulin, factors characteristic for type 1 and 2 diabetes. |
| 2 | 23319319 | High ambient glucose inhibited myogenesis of C2C12 myoblasts, an effect manifested by a twofold decrease in myoblast fusion, a drop in intracellular MyoD, myogenin and MHC levels, and increased cellular content of active myostatin isoform. |
| 3 | 23319319 | Reduction in myogenesis by high glucose is accompanied by increase in cellular levels of IGFBP-4 and -6 and decrease in IGFBP-5. |
| 4 | 23319319 | In contrast, high glucose and high insulin activate myoblast differentiation, manifested by an increase in fusion index and myogenin, as well as a drop in myostatin levels. |