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Gene Information
Gene symbol: ADAM28
Gene name: ADAM metallopeptidase domain 28
HGNC ID: 206
Synonyms: eMDCII, MDC-Lm, MDC-Ls, ADAM23
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAMTS3 | 1 hits |
| 2 | ADAMTS4 | 1 hits |
| 3 | GLI2 | 1 hits |
| 4 | MMP9 | 1 hits |
| 5 | PPARA | 1 hits |
| 6 | PPARG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14534304 | Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
| 2 | 14534304 | The PPAR gamma agonists, thiazolidinediones (TZDs), have anti-inflammatory properties as well as increasing insulin sensitivity. |
| 3 | 14534304 | This study aims to identify other metalloproteinase genes of the ADAM (A Disintegin And Metalloproteinase) and ADAMTS families that are regulated by PPAR gamma or RXR agonists, which are potentially important in type 2 diabetes and/or related atherosclerosis. |
| 4 | 14534304 | The synthetic PPAR gamma agonist, GW7845, and the natural agonist 15d-PGJ2, suppressed PMA stimulated MMP-9 in human monocyte-like cells (THP-1) only in the presence of 9-cis-retinoic acid. |
| 5 | 14534304 | Expression of ADAMs 8, 9, and 17 were increased, and ADAM15 was decreased by stimulation of THP-1 with PMA, although these ADAMs were not regulated by PPAR gamma or RXR agonists. |
| 6 | 14534304 | ADAMTS4, implicated in rheumatoid arthritis, was expressed in THP-1 cells, and significantly increased after 24 h of PMA stimulation. |
| 7 | 14534304 | ADAMTS4 expression was suppressed by both PPAR gamma and RXR agonists and was undetectable when the agonists were combined. |
| 8 | 14534304 | Pretreatment of THP-1 cells with the PPAR gamma antagonist, GW9662, suggests that PPAR gamma plays subtly different roles in the regulation of MMP-9, ADAMTS4 and ADAM28 gene expression. |
| 9 | 14534304 | These results indicate that PPAR gamma and RXR agonists have complex effects on monocyte metalloproteinase expression, which may have implications for therapeutic strategies. |