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Gene Information
Gene symbol: ADAM8
Gene name: ADAM metallopeptidase domain 8
HGNC ID: 215
Synonyms: CD156, MS2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAM15 | 1 hits |
| 2 | ADAM17 | 1 hits |
| 3 | ADAM9 | 1 hits |
| 4 | CD68 | 1 hits |
| 5 | MGMT | 1 hits |
| 6 | NHEJ1 | 1 hits |
| 7 | NRCAM | 1 hits |
| 8 | PAK3 | 1 hits |
| 9 | PPARA | 1 hits |
| 10 | PPARG | 1 hits |
| 11 | TNFRSF10C | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14534304 | Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
| 2 | 14534304 | The PPAR gamma agonists, thiazolidinediones (TZDs), have anti-inflammatory properties as well as increasing insulin sensitivity. |
| 3 | 14534304 | This study aims to identify other metalloproteinase genes of the ADAM (A Disintegin And Metalloproteinase) and ADAMTS families that are regulated by PPAR gamma or RXR agonists, which are potentially important in type 2 diabetes and/or related atherosclerosis. |
| 4 | 14534304 | The synthetic PPAR gamma agonist, GW7845, and the natural agonist 15d-PGJ2, suppressed PMA stimulated MMP-9 in human monocyte-like cells (THP-1) only in the presence of 9-cis-retinoic acid. |
| 5 | 14534304 | Expression of ADAMs 8, 9, and 17 were increased, and ADAM15 was decreased by stimulation of THP-1 with PMA, although these ADAMs were not regulated by PPAR gamma or RXR agonists. |
| 6 | 14534304 | ADAMTS4, implicated in rheumatoid arthritis, was expressed in THP-1 cells, and significantly increased after 24 h of PMA stimulation. |
| 7 | 14534304 | ADAMTS4 expression was suppressed by both PPAR gamma and RXR agonists and was undetectable when the agonists were combined. |
| 8 | 14534304 | Pretreatment of THP-1 cells with the PPAR gamma antagonist, GW9662, suggests that PPAR gamma plays subtly different roles in the regulation of MMP-9, ADAMTS4 and ADAM28 gene expression. |
| 9 | 14534304 | These results indicate that PPAR gamma and RXR agonists have complex effects on monocyte metalloproteinase expression, which may have implications for therapeutic strategies. |
| 10 | 18692406 | Linear ion-trap (LIT) MS2 mass spectrometric approach toward locating the position of double bond(s) of unsaturated long-chain fatty acids and toward discerning among isomeric unsaturated fatty acids as dilithiated adduct ([M-H+2Li]+) ions are described in this report. |
| 11 | 23038007 | In contrast, cytochrome P450 family 4, subfamily a, polypeptide 8 (Cyp4a8), and monocyte to macrophage differentiation-associated (Mmd2) were down-regulated relative to controls. |
| 12 | 23038007 | Possible biomarkers due to 2AA toxicity in the liver for future study include Abcb1a, Nhej1, Adam8, Cdkn1a, Mgmt, and Nrcam. |
| 13 | 23700340 | Furthermore, gene expression of macrophage-specific markers ADAM8 (A disintegrin and metalloproteinase domain-containing protein 8) and CD68 (cluster of differentiation 68) was significantly greater in adipose tissue in the HFD-Zn group than in the HFD group, as confirmed by CD68 protein analysis, indicative of increased macrophage infiltration. |