- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: ADAMTS1
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif, 1
HGNC ID: 217
Synonyms: C3-C5, METH1, KIAA1346
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD79A | 1 hits |
| 2 | CDC34 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 3548335 | Utilizing a monoclonal antibody (Poly C9-MA) to a neoantigen of the C9 portion of the membrane attack complex of complement (MAC), immunoelectron (IEM) and immunofluorescent (IF) microscopy were performed on kidney tissue from normal humans and patients with insulin-dependent diabetes mellitus (IDDM) and type II membrano-proliferative glomerulonephritis (MPGN II). |
| 2 | 3548335 | Comparative studies were conducted using polyclonal antibodies to human C3, C5, IgG, IgA, and IgM. |
| 3 | 10681643 | The balance between glucocorticoids and insulin regulates muscle proteolysis via the ubiquitin-proteasome pathway. |
| 4 | 10681643 | In muscles of STZ-diabetic rats, the levels of ubiquitin-conjugated proteins and mRNAs encoding ubiquitin, the ubiquitin-carrier protein, E2(14k) and the C3, C5 and C9 proteasome subunits were increased. |
| 5 | 10681643 | Transcription of ubiquitin and C3 proteasome subunit genes in muscle was also increased by IDDM. |
| 6 | 10681643 | Corticosterone excretion was higher in IDDM rats and adrenalectomy (ADX) prevented these catabolic responses; physiologic doses of glucorcoticoids restored the excessive protein catabolism in ADX-STZ rats. |
| 7 | 10681643 | Giving IDDM rats replacement insulin also normalized protein degradation in muscles. |
| 8 | 10681643 | In conclusion, reduced insulin together with physiologic levels of glucocorticoids activate the ubiquitin-proteasome pathway by a mechanism that includes enhancing ubiquitin conjugation and proteolysis by the proteasome. |