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Gene Information
Gene symbol: ADAMTS5
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif, 5
HGNC ID: 221
Synonyms: ADMP-2, ADAMTS11
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAMTS3 | 1 hits |
| 2 | APLN | 1 hits |
| 3 | INS | 1 hits |
| 4 | TNF | 1 hits |
| 5 | TNFSF11 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19010456 | These changes were accompanied by diabetes-increased mRNA levels of RANKL, TNF-alpha, and ADAMTS-4 and -5 measured by real-time PCR, which was reversed by insulin treatment. |
| 2 | 20664951 | In vitro, we examined the effects of apelin on normal chondrocyte proliferation and gene expression of metalloproteinases (MMPs) and interleukin-1beta (IL-1beta). |
| 3 | 20664951 | In vivo, by intra-articular injection with apelin, we examined MMP-3, -9, collagen II and IL-1beta at both gene and protein levels. |
| 4 | 20664951 | Furthermore, we measured the messenger RNA (mRNA) expression of ADAMTS-4 and -5 (a disintegrin and metalloproteinase with thrombospondin motifs 4 and 5) and the proteoglycan content in articular cartilage. |
| 5 | 20664951 | Apelin stimulated the proliferation of chondrocytes and significantly increased mRNA levels of MMP-1, -3, -9 and IL-1beta in vitro. |
| 6 | 20664951 | Intra-articular injection with apelin in vivo up-regulated the expression of MMP-3, -9, and IL-1beta as well as decreased the level of collagen II. |
| 7 | 20664951 | Additionally, after treatment with apelin, mRNA levels of ADAMTS-4 and -5 markedly increased and depletion of proteoglycan in articular cartilage was found by histological assessment. |
| 8 | 20664951 | In vitro, we examined the effects of apelin on normal chondrocyte proliferation and gene expression of metalloproteinases (MMPs) and interleukin-1beta (IL-1beta). |
| 9 | 20664951 | In vivo, by intra-articular injection with apelin, we examined MMP-3, -9, collagen II and IL-1beta at both gene and protein levels. |
| 10 | 20664951 | Furthermore, we measured the messenger RNA (mRNA) expression of ADAMTS-4 and -5 (a disintegrin and metalloproteinase with thrombospondin motifs 4 and 5) and the proteoglycan content in articular cartilage. |
| 11 | 20664951 | Apelin stimulated the proliferation of chondrocytes and significantly increased mRNA levels of MMP-1, -3, -9 and IL-1beta in vitro. |
| 12 | 20664951 | Intra-articular injection with apelin in vivo up-regulated the expression of MMP-3, -9, and IL-1beta as well as decreased the level of collagen II. |
| 13 | 20664951 | Additionally, after treatment with apelin, mRNA levels of ADAMTS-4 and -5 markedly increased and depletion of proteoglycan in articular cartilage was found by histological assessment. |