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Gene Information
Gene symbol: ADCY8
Gene name: adenylate cyclase 8 (brain)
HGNC ID: 239
Synonyms: HBAC1, AC8
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADCY1 | 1 hits |
| 2 | ADCY2 | 1 hits |
| 3 | ADCY3 | 1 hits |
| 4 | ADCY4 | 1 hits |
| 5 | ADCY7 | 1 hits |
| 6 | GCG | 1 hits |
| 7 | INS | 1 hits |
| 8 | WFS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10766260 | These effects of forskolin were associated with overexpression of type-3 adenylyl cyclase (AC) mRNA due to the presence of two functional point mutations in the promoter region of AC3 gene in GK rat. |
| 2 | 10766260 | Moreover, we have found an increased IR of the Ca2+-stimulated ACl, AC3 and AC8 in diabetic beta- and alpha-cells, compared with the corresponding IR in control pancreas. |
| 3 | 12950106 | The most abundant isoforms appeared to be AC2, AC3, and AC8, each with distinct distributions in the acrosomal and flagellar regions; AC1 and AC4 also appeared to be present, although less abundantly, in the midpiece and acrosomal cap regions, respectively. |
| 4 | 12950106 | Of particular interest were AC3 and AC8, located in the same regions as, and hence possibly directly associated with, specific cell surface receptors and G proteins that are able to regulate the spermatozoon's acquisition and maintenance of fertilizing ability via changes in AC/cAMP. |
| 5 | 12950106 | The most abundant isoforms appeared to be AC2, AC3, and AC8, each with distinct distributions in the acrosomal and flagellar regions; AC1 and AC4 also appeared to be present, although less abundantly, in the midpiece and acrosomal cap regions, respectively. |
| 6 | 12950106 | Of particular interest were AC3 and AC8, located in the same regions as, and hence possibly directly associated with, specific cell surface receptors and G proteins that are able to regulate the spermatozoon's acquisition and maintenance of fertilizing ability via changes in AC/cAMP. |
| 7 | 22983116 | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. |
| 8 | 22983116 | Here we provide evidence that WFS1 is essential for glucose- and glucagon-like peptide 1 (GLP-1)-stimulated cyclic AMP production and regulation of insulin biosynthesis and secretion. |
| 9 | 22983116 | Stimulation with glucose causes WFS1 translocation from the ER to the plasma membrane, where it forms a complex with adenylyl cyclase 8 (AC8), an essential cAMP-generating enzyme in the β-cell that integrates glucose and GLP-1 signalling. |
| 10 | 22983116 | ER stress and mutant WFS1 inhibit complex formation and activation of AC8, reducing cAMP synthesis and insulin secretion. |
| 11 | 22983116 | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. |
| 12 | 22983116 | Here we provide evidence that WFS1 is essential for glucose- and glucagon-like peptide 1 (GLP-1)-stimulated cyclic AMP production and regulation of insulin biosynthesis and secretion. |
| 13 | 22983116 | Stimulation with glucose causes WFS1 translocation from the ER to the plasma membrane, where it forms a complex with adenylyl cyclase 8 (AC8), an essential cAMP-generating enzyme in the β-cell that integrates glucose and GLP-1 signalling. |
| 14 | 22983116 | ER stress and mutant WFS1 inhibit complex formation and activation of AC8, reducing cAMP synthesis and insulin secretion. |
| 15 | 22983116 | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. |
| 16 | 22983116 | Here we provide evidence that WFS1 is essential for glucose- and glucagon-like peptide 1 (GLP-1)-stimulated cyclic AMP production and regulation of insulin biosynthesis and secretion. |
| 17 | 22983116 | Stimulation with glucose causes WFS1 translocation from the ER to the plasma membrane, where it forms a complex with adenylyl cyclase 8 (AC8), an essential cAMP-generating enzyme in the β-cell that integrates glucose and GLP-1 signalling. |
| 18 | 22983116 | ER stress and mutant WFS1 inhibit complex formation and activation of AC8, reducing cAMP synthesis and insulin secretion. |