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Gene Information
Gene symbol: ALS2
Gene name: amyotrophic lateral sclerosis 2 (juvenile)
HGNC ID: 443
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IGFALS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7595601 | The insulin-like growth factor signaling system and ALS neurotrophic factor treatment strategies. |
| 2 | 7595601 | Because of its multi-faceted potential as a neurotrophic factor, insulin-like growth factor I (IGF-I) has been given to hundreds of ALS patients world-wide. |
| 3 | 7595601 | We found that about 25% of ALS patients in a controlled trial of human growth hormone (hGH) had lower or higher than normal IGF-I serum levels. |
| 4 | 7595601 | Many ALS patients do have some of the characteristics of type II diabetes mellitus, where IGF-I therapy is also under way. |
| 5 | 7595601 | In addition, in type I diabetes significant increase in a circulating molecule that binds IGF-I, IGF-I binding protein 1 (IGFBP-1), occurs along with reduced IGF-I, when neuropathic complications are prominent. |
| 6 | 7595601 | We have studied the response of IGFBPs in ALS patients to subcutaneous rhIGF-I and found transient induction of IGFBP-1. |
| 7 | 7595601 | However, the gene for another IGFBP, BP-2, co-localizes with the gene for juvenile ALS (ALSJ) on chromosome 2. |