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Gene Information
Gene symbol: AP3S2
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GRB14 | 1 hits |
| 2 | HMG20A | 1 hits |
| 3 | HNF4A | 1 hits |
| 4 | KCNK16 | 1 hits |
| 5 | NOTCH2 | 1 hits |
| 6 | ST6GAL1 | 1 hits |
| 7 | VPS26A | 1 hits |
| 8 | WFS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21874001 | In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)). |
| 2 | 21874001 | SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10(-4)), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). |
| 3 | 23372846 | Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology. |
| 4 | 23372846 | At six loci with genome-wide evidence for T2D association (AP3S2, KCNK16, NOTCH2, SCL30A8, VPS26A, and WFS1) predicted mRNA target sites for islet-expressed miRNAs overlapped potentially causal variants. |