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Gene Information
Gene symbol: APEX1
Gene name: APEX nuclease (multifunctional DNA repair enzyme) 1
HGNC ID: 587
Synonyms: APE, REF1, HAP1, APX, APEN, REF-1, APE-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATM | 1 hits |
| 2 | IPPK | 1 hits |
| 3 | MAPK1 | 1 hits |
| 4 | NFE2L2 | 1 hits |
| 5 | PI3 | 1 hits |
| 6 | SHC1 | 1 hits |
| 7 | TXN | 1 hits |
| 8 | XRCC3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8736558 | The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal. |
| 2 | 11348594 | The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate reveals a fold and an active site His and Asp pair resembling those of several Mg(2+)-dependent nucleases. |
| 3 | 11348594 | The 4-phosphate of inositol (1,4)-bisphosphate is misoriented by 4.6 compared to the reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphorylation site selectivity of the 5-phosphatases. |
| 4 | 18712175 | APE1 and XRCC3 polymorphisms and myocardial infarction. |
| 5 | 22286106 | This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases, PI3 kinase, PTEN, and protein tyrosine phosphatases), ROS homeostasis and antioxidant gene regulation (thioredoxin, peroxiredoxin, Ref-1, and Nrf-2), mitochondrial oxidative stress, apoptosis, and aging (p66Shc), iron homeostasis through iron-sulfur cluster proteins (IRE-IRP), and ATM-regulated DNA damage response. |