Ignet

Gene Information

Gene symbol: AQP7

Gene name: aquaporin 7

HGNC ID: 640

Synonyms: AQP9, AQPap

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	AQP1	1 hits
3	AQP2	1 hits
4	AQP3	1 hits
5	AQP4	1 hits
6	AQP5	1 hits
7	AQP6	1 hits
8	AQP8	1 hits
9	AQP9	1 hits
10	C10orf10	1 hits
11	INS	1 hits
12	MIP	1 hits
13	PNPLA2	1 hits
14	PPARA	1 hits
15	SAT1	1 hits
16	SLC2A4	1 hits

Related Sentences

#	PMID	Sentence
1	10073616	This concerns inherited forms of nephrogenic diabetes insipidus and several, much more common acquired types of nephrogenic diabetes insipidus where AQP2 expression and/or targeting are affected.
2	10073616	AQP3 and AQP4 are basolateral water channels located in the kidney collecting duct, and AQP6 and AQP7 appear to be expressed at lower abundance at several sites including the proximal tubule.
3	11457862	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
4	11457862	Insulin down-regulated AQPap mRNA in 3T3-L1 adipocytes.
5	11457862	The AQPap promoter contained heptanucleotide sequences, TGTTTTT at -443/-437, similar to the insulin-response element identified previously in the promoters of insulin-repressed genes.
6	11457862	Deletion and single base pair substitution analysis of the promoter revealed that these sequences were required for insulin-mediated repression of AQPap gene transcription.
7	11457862	We conclude that insulin represses the transcription of AQPap gene via insulin response element in its promoter.
8	11457862	Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol.
9	11457862	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
10	11457862	Insulin down-regulated AQPap mRNA in 3T3-L1 adipocytes.
11	11457862	The AQPap promoter contained heptanucleotide sequences, TGTTTTT at -443/-437, similar to the insulin-response element identified previously in the promoters of insulin-repressed genes.
12	11457862	Deletion and single base pair substitution analysis of the promoter revealed that these sequences were required for insulin-mediated repression of AQPap gene transcription.
13	11457862	We conclude that insulin represses the transcription of AQPap gene via insulin response element in its promoter.
14	11457862	Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol.
15	11457862	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
16	11457862	Insulin down-regulated AQPap mRNA in 3T3-L1 adipocytes.
17	11457862	The AQPap promoter contained heptanucleotide sequences, TGTTTTT at -443/-437, similar to the insulin-response element identified previously in the promoters of insulin-repressed genes.
18	11457862	Deletion and single base pair substitution analysis of the promoter revealed that these sequences were required for insulin-mediated repression of AQPap gene transcription.
19	11457862	We conclude that insulin represses the transcription of AQPap gene via insulin response element in its promoter.
20	11457862	Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol.
21	11457862	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
22	11457862	Insulin down-regulated AQPap mRNA in 3T3-L1 adipocytes.
23	11457862	The AQPap promoter contained heptanucleotide sequences, TGTTTTT at -443/-437, similar to the insulin-response element identified previously in the promoters of insulin-repressed genes.
24	11457862	Deletion and single base pair substitution analysis of the promoter revealed that these sequences were required for insulin-mediated repression of AQPap gene transcription.
25	11457862	We conclude that insulin represses the transcription of AQPap gene via insulin response element in its promoter.
26	11457862	Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol.
27	11457862	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
28	11457862	Insulin down-regulated AQPap mRNA in 3T3-L1 adipocytes.
29	11457862	The AQPap promoter contained heptanucleotide sequences, TGTTTTT at -443/-437, similar to the insulin-response element identified previously in the promoters of insulin-repressed genes.
30	11457862	Deletion and single base pair substitution analysis of the promoter revealed that these sequences were required for insulin-mediated repression of AQPap gene transcription.
31	11457862	We conclude that insulin represses the transcription of AQPap gene via insulin response element in its promoter.
32	11457862	Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol.
33	11457862	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
34	11457862	Insulin down-regulated AQPap mRNA in 3T3-L1 adipocytes.
35	11457862	The AQPap promoter contained heptanucleotide sequences, TGTTTTT at -443/-437, similar to the insulin-response element identified previously in the promoters of insulin-repressed genes.
36	11457862	Deletion and single base pair substitution analysis of the promoter revealed that these sequences were required for insulin-mediated repression of AQPap gene transcription.
37	11457862	We conclude that insulin represses the transcription of AQPap gene via insulin response element in its promoter.
38	11457862	Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol.
39	12097826	In kidney, AQP1 is expressed in plasma membranes of proximal tubule, thin descending limb of Henle and descending vasa recta, AQP2 in collecting duct luminal membrane, AQP3 and AQP4 in collecting duct basolateral membrane, AQP6 in intercalated cells, and AQP7 in the S3 segment of proximal tubule.
40	12097826	Human mutations in AQP2 cause hereditary non-X-linked nephrogenic diabetes insipidus.
41	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
42	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
43	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
44	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
45	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
46	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
47	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
48	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
49	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
50	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
51	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
52	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
53	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
54	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
55	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
56	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
57	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
58	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
59	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
60	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
61	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
62	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
63	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
64	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
65	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
66	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
67	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
68	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
69	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
70	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
71	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
72	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
73	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
74	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
75	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
76	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
77	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
78	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
79	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
80	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
81	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
82	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
83	12351427	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
84	12351427	In the present study, we cloned the coding and promoter regions of mouse aquaporin 9 (AQP9), a liver-specific glycerol channel.
85	12351427	Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA.
86	12351427	In cultured hepatocytes, insulin downregulated AQP9 mRNA.
87	12351427	The AQP9 promoter contained the negative insulin response element TGTTTTC at -496/-502, similar to the promoter of the AQPap/7 gene.
88	12351427	In contrast, in insulin-resistant db+/db+ mice, AQPap/7 mRNA in fat and AQP9 mRNA in liver were increased, despite hyperinsulinemia, with high plasma glycerol and glucose levels.
89	12351427	Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance.
90	16537077	The presence of AQP1, AQP5 and AQP8 has been generally accepted by many, while the presence of AQP3, AQP4, AQP6 and AQP7 still remains controversial.
91	16713493	Mice lacking functional AQP2, AQP3, or AQP4 manifest various degrees of nephrogenic diabetes insipidus resulting from reduced collecting duct water permeability.
92	16713493	Mice lacking AQP7 and AQP8 can concentrate their urine fully, although AQP7 null mice manifest an interesting defect in glycerol reabsorption.
93	16713493	Two unexpected renal phenotypes of AQP null mice have been discovered recently, including defective proximal tubule cell migration in AQP1 deficiency, and cystic renal disease in AQP11 deficiency.
94	16919625	AQP7 modulates adipocyte glycerol permeability thereby controlling triglyceride accumulation and fat cell size.
95	16919625	Furthermore, the coordinated regulation of fat-specific AQP7 and liver-specific AQP9 may be key to determine glucose metabolism in insulin resistance.
96	16919625	AQP7 modulates adipocyte glycerol permeability thereby controlling triglyceride accumulation and fat cell size.
97	16919625	Furthermore, the coordinated regulation of fat-specific AQP7 and liver-specific AQP9 may be key to determine glucose metabolism in insulin resistance.
98	17077387	Aquaporin (AQP7) is expressed in proximal tubules and is involved in glycerol uptake.
99	17077387	At the cellular level, the capillary endothelium WAT and BAT displayed prominent staining, whereas AQP7 labeling in adipocyte membranes was undetectable.
100	17077387	Double-labeling confocal microscopy revealed coexpression of AQP7 with capillary AQP1 but not with adipocyte GLUT4.
101	17077387	Aquaporin (AQP7) is expressed in proximal tubules and is involved in glycerol uptake.
102	17077387	At the cellular level, the capillary endothelium WAT and BAT displayed prominent staining, whereas AQP7 labeling in adipocyte membranes was undetectable.
103	17077387	Double-labeling confocal microscopy revealed coexpression of AQP7 with capillary AQP1 but not with adipocyte GLUT4.
104	17077387	Aquaporin (AQP7) is expressed in proximal tubules and is involved in glycerol uptake.
105	17077387	At the cellular level, the capillary endothelium WAT and BAT displayed prominent staining, whereas AQP7 labeling in adipocyte membranes was undetectable.
106	17077387	Double-labeling confocal microscopy revealed coexpression of AQP7 with capillary AQP1 but not with adipocyte GLUT4.
107	17245390	Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.
108	17351148	A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.
109	17351148	Aquaporin 7 (AQP7), the gateway protein controlling glycerol release, has recently emerged as a modulator of adipocyte metabolism.
110	17351148	Luciferase and mobility shift assays showed that, compared with -953A, the -953G promoter had reduced transcriptional activity (P = 0.001) and impaired ability to bind CCAAT/enhancer binding protein (C/EBP)beta transcription factor (P = 0.01).
111	17351148	A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.
112	17351148	Aquaporin 7 (AQP7), the gateway protein controlling glycerol release, has recently emerged as a modulator of adipocyte metabolism.
113	17351148	Luciferase and mobility shift assays showed that, compared with -953A, the -953G promoter had reduced transcriptional activity (P = 0.001) and impaired ability to bind CCAAT/enhancer binding protein (C/EBP)beta transcription factor (P = 0.01).
114	17576812	To investigate if intracellular glycerol content plays a role in the regulation of insulin secretion in pancreatic beta cells, we studied the expression of the glycerol channels, or aquaglyceroporins, encoded by the aquaporin 3 (Aqp3), Aqp7, and Aqp9 genes in mouse islets.
115	17576812	We found expression of Aqp7 only, not that of Aqp3 or Aqp9, in the endocrine pancreas at both the mRNA (by reverse transcription-PCR) and protein (by immunohistochemistry) levels.
116	17576812	To investigate if intracellular glycerol content plays a role in the regulation of insulin secretion in pancreatic beta cells, we studied the expression of the glycerol channels, or aquaglyceroporins, encoded by the aquaporin 3 (Aqp3), Aqp7, and Aqp9 genes in mouse islets.
117	17576812	We found expression of Aqp7 only, not that of Aqp3 or Aqp9, in the endocrine pancreas at both the mRNA (by reverse transcription-PCR) and protein (by immunohistochemistry) levels.
118	18401671	Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver.
119	19615702	The trafficking of glycerol from adipose and hepatic tissue is mainly mediated by 2 aquaporin channel proteins: AQP7 and AQP9, respectively.
120	19615702	Real-time quantification of AQP7 in SAT and VAT and hepatic AQP9 gene expression were performed.
121	19615702	Visceral adipose tissue AQP7 expression levels were significantly higher than SAT AQP7 (P = .009).
122	19615702	The correlation between SAT AQP7 and liver AQP9 was stronger in intolerant and type 2 diabetes mellitus subjects (r = 0.602, P = .011).
123	19615702	The trafficking of glycerol from adipose and hepatic tissue is mainly mediated by 2 aquaporin channel proteins: AQP7 and AQP9, respectively.
124	19615702	Real-time quantification of AQP7 in SAT and VAT and hepatic AQP9 gene expression were performed.
125	19615702	Visceral adipose tissue AQP7 expression levels were significantly higher than SAT AQP7 (P = .009).
126	19615702	The correlation between SAT AQP7 and liver AQP9 was stronger in intolerant and type 2 diabetes mellitus subjects (r = 0.602, P = .011).
127	19615702	The trafficking of glycerol from adipose and hepatic tissue is mainly mediated by 2 aquaporin channel proteins: AQP7 and AQP9, respectively.
128	19615702	Real-time quantification of AQP7 in SAT and VAT and hepatic AQP9 gene expression were performed.
129	19615702	Visceral adipose tissue AQP7 expression levels were significantly higher than SAT AQP7 (P = .009).
130	19615702	The correlation between SAT AQP7 and liver AQP9 was stronger in intolerant and type 2 diabetes mellitus subjects (r = 0.602, P = .011).
131	19615702	The trafficking of glycerol from adipose and hepatic tissue is mainly mediated by 2 aquaporin channel proteins: AQP7 and AQP9, respectively.
132	19615702	Real-time quantification of AQP7 in SAT and VAT and hepatic AQP9 gene expression were performed.
133	19615702	Visceral adipose tissue AQP7 expression levels were significantly higher than SAT AQP7 (P = .009).
134	19615702	The correlation between SAT AQP7 and liver AQP9 was stronger in intolerant and type 2 diabetes mellitus subjects (r = 0.602, P = .011).
135	19937567	Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver.
136	19937567	We analyzed the profile of the genes expressed in human adipose tissue and identified the fat-derived molecules, adiponectin and aquaporin 7, which modulate glucose and lipid metabolism.
137	19937567	Because fasting-induced DEPP expression was observed in insulin-sensitive organs, we investigated the regulation of DEPP in white adipose tissue and liver.
138	19937567	During adipogenesis of mouse 3T3-L1 cells, DEPP mRNA increased in a differentiation-dependent manner similar to adiponectin and aquaporin 7.
139	19937567	Treatment of cultured 3T3-L1 mature adipocytes, rat H4IIE, and human HepG2 hepatoma cells with insulin significantly decreased DEPP mRNA levels in dose- and time-dependent manners.
140	19937567	IN VIVO experiments showed significant decrease of hepatic and adipose DEPP mRNA levels in refed mice, compared to fasted animals, and also showed significant increase in DEPP mRNA in streptozotocin-induced insulin-deficient diabetic mice.
141	19937567	These results indicate that DEPP is a novel insulin-regulatory molecule expressed abundantly in insulin-sensitive tissues including white adipose tissue and liver.
142	19937567	Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver.
143	19937567	We analyzed the profile of the genes expressed in human adipose tissue and identified the fat-derived molecules, adiponectin and aquaporin 7, which modulate glucose and lipid metabolism.
144	19937567	Because fasting-induced DEPP expression was observed in insulin-sensitive organs, we investigated the regulation of DEPP in white adipose tissue and liver.
145	19937567	During adipogenesis of mouse 3T3-L1 cells, DEPP mRNA increased in a differentiation-dependent manner similar to adiponectin and aquaporin 7.
146	19937567	Treatment of cultured 3T3-L1 mature adipocytes, rat H4IIE, and human HepG2 hepatoma cells with insulin significantly decreased DEPP mRNA levels in dose- and time-dependent manners.
147	19937567	IN VIVO experiments showed significant decrease of hepatic and adipose DEPP mRNA levels in refed mice, compared to fasted animals, and also showed significant increase in DEPP mRNA in streptozotocin-induced insulin-deficient diabetic mice.
148	19937567	These results indicate that DEPP is a novel insulin-regulatory molecule expressed abundantly in insulin-sensitive tissues including white adipose tissue and liver.
149	23001483	In the present study, we aimed to test the hypotheses that (1) AQP7 is localized to the capillaries within human adipose tissue, (2) genetic predisposition to type-2 diabetes is associated with a low expression of AQP7 in abdominal subcutaneous adipose tissue (SAT) and (3) physical training increases AQP7 expression in SAT.
150	23001483	The relative expression of AQP7 protein in abdominal SAT was analysed before and after ending a 10-week exercise training programme in first-degree relatives to type-2 diabetic patients and control individuals.
151	23001483	We were unable to evidence a link between a low AQP7 abundance in SAT and genetic predisposition type-2 diabetes.
152	23001483	Instead we demonstrate that physical training influences the expression of AQP7 in SAT in a gender-specific manner.
153	23001483	In conclusion, the adipose tissue glycerol channel, AQP7, is regulated in response to physical training in a gender-dependent manner in SAT.
154	23001483	In the present study, we aimed to test the hypotheses that (1) AQP7 is localized to the capillaries within human adipose tissue, (2) genetic predisposition to type-2 diabetes is associated with a low expression of AQP7 in abdominal subcutaneous adipose tissue (SAT) and (3) physical training increases AQP7 expression in SAT.
155	23001483	The relative expression of AQP7 protein in abdominal SAT was analysed before and after ending a 10-week exercise training programme in first-degree relatives to type-2 diabetic patients and control individuals.
156	23001483	We were unable to evidence a link between a low AQP7 abundance in SAT and genetic predisposition type-2 diabetes.
157	23001483	Instead we demonstrate that physical training influences the expression of AQP7 in SAT in a gender-specific manner.
158	23001483	In conclusion, the adipose tissue glycerol channel, AQP7, is regulated in response to physical training in a gender-dependent manner in SAT.
159	23001483	In the present study, we aimed to test the hypotheses that (1) AQP7 is localized to the capillaries within human adipose tissue, (2) genetic predisposition to type-2 diabetes is associated with a low expression of AQP7 in abdominal subcutaneous adipose tissue (SAT) and (3) physical training increases AQP7 expression in SAT.
160	23001483	The relative expression of AQP7 protein in abdominal SAT was analysed before and after ending a 10-week exercise training programme in first-degree relatives to type-2 diabetic patients and control individuals.
161	23001483	We were unable to evidence a link between a low AQP7 abundance in SAT and genetic predisposition type-2 diabetes.
162	23001483	Instead we demonstrate that physical training influences the expression of AQP7 in SAT in a gender-specific manner.
163	23001483	In conclusion, the adipose tissue glycerol channel, AQP7, is regulated in response to physical training in a gender-dependent manner in SAT.
164	23001483	In the present study, we aimed to test the hypotheses that (1) AQP7 is localized to the capillaries within human adipose tissue, (2) genetic predisposition to type-2 diabetes is associated with a low expression of AQP7 in abdominal subcutaneous adipose tissue (SAT) and (3) physical training increases AQP7 expression in SAT.
165	23001483	The relative expression of AQP7 protein in abdominal SAT was analysed before and after ending a 10-week exercise training programme in first-degree relatives to type-2 diabetic patients and control individuals.
166	23001483	We were unable to evidence a link between a low AQP7 abundance in SAT and genetic predisposition type-2 diabetes.
167	23001483	Instead we demonstrate that physical training influences the expression of AQP7 in SAT in a gender-specific manner.
168	23001483	In conclusion, the adipose tissue glycerol channel, AQP7, is regulated in response to physical training in a gender-dependent manner in SAT.
169	23001483	In the present study, we aimed to test the hypotheses that (1) AQP7 is localized to the capillaries within human adipose tissue, (2) genetic predisposition to type-2 diabetes is associated with a low expression of AQP7 in abdominal subcutaneous adipose tissue (SAT) and (3) physical training increases AQP7 expression in SAT.
170	23001483	The relative expression of AQP7 protein in abdominal SAT was analysed before and after ending a 10-week exercise training programme in first-degree relatives to type-2 diabetic patients and control individuals.
171	23001483	We were unable to evidence a link between a low AQP7 abundance in SAT and genetic predisposition type-2 diabetes.
172	23001483	Instead we demonstrate that physical training influences the expression of AQP7 in SAT in a gender-specific manner.
173	23001483	In conclusion, the adipose tissue glycerol channel, AQP7, is regulated in response to physical training in a gender-dependent manner in SAT.