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Gene Information
Gene symbol: ARRDC3
Gene name: arrestin domain containing 3
HGNC ID: 29263
Synonyms: KIAA1376
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ARRDC4 | 1 hits |
| 2 | TXN | 1 hits |
| 3 | TXNIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23519408 | Various stress stimuli such as high glucose, heat shock, UV, H2O2 and mechanical stress among others robustly induce the expression of TXNIP, resulting in the sequestration and inactivation of thioredoxin, which in turn leads to cellular oxidative stress. |
| 2 | 23519408 | While TXNIP is the only α-arrestin known to bind thioredoxin, TXNIP and two other α-arrestins, Arrdc4 and Arrdc3, have been implicated in metabolism. |
| 3 | 23519408 | It provides the first structural information on any of the α-arrestins and reveals that although TXNIP adopts a β-arrestin fold as predicted, it is structurally more similar to Vps26 proteins than to β-arrestins, while sharing below 15% pairwise sequence identity with either. |