Ignet

Gene Information

Gene symbol: ATF1

Gene name: activating transcription factor 1

HGNC ID: 783

Synonyms: TREB36

Related Genes

#	Gene Symbol	Number of hits
1	ATF3	1 hits
2	ATF4	1 hits
3	CREB1	1 hits
4	CREM	1 hits
5	GCG	1 hits
6	HNF1A	1 hits
7	IGF1	1 hits
8	INS	1 hits
9	PRKAR2A	1 hits

Related Sentences

#	PMID	Sentence
1	12167488	Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications.
2	12167488	GLP-1 enhances both insulin secretion and insulin gene expression in a glucose-dependent manner via activation of its putative G-protein-coupled receptor on pancreatic beta-cells.
3	12167488	Analysis of intracellular signaling components revealed that DMSO did not elevate cAMP levels, protein kinase A activity, or phosphorylated levels of CRE-binding protein (CREB), CRE-modulator (CREM), and activating transcription factor-1 (ATF-1).
4	12167488	These data suggest that GLP-1 induces insulin gene transcription in a CREB, CREM, and ATF-1-independent manner in beta-cells.
5	23568554	The transcription factor cAMP responsive element-binding protein (CREB) and activating transcription factors (ATFs) are downstream components of the insulin/IGF cascade, playing crucial roles in maintaining cell viability and embryo survival.
6	23568554	One of the CREB target genes is adiponectin, which acts synergistically with insulin.
7	23568554	We have studied the CREB-ATF-adiponectin network in rabbit preimplantation development in vivo and in vitro.
8	23568554	From the blastocyst stage onwards, CREB and ATF1, ATF3, and ATF4 are present with increasing expression for CREB, ATF1, and ATF3 during gastrulation and with a dominant expression in the embryoblast (EB).
9	23568554	In vitro stimulation with insulin and IGF-I reduced CREB and ATF1 transcripts by approximately 50%, whereas CREB phosphorylation was increased.
10	23568554	Activation of CREB was accompanied by subsequent reduction in adiponectin and adiponectin receptor (adipoR)1 expression.
11	23568554	Analysis of embryonic adipoRs showed an increased expression of adipoR1 and no changes in adipoR2 transcription.
12	23568554	We conclude that the transcription factors CREB and ATFs vitally participate in embryo-maternal cross talk before implantation in a cell lineage-specific manner.
13	23568554	Embryonic CREB/ATFs act as insulin/IGF sensors.
14	23568554	Lack of insulin is compensated by a CREB-mediated adiponectin expression, which may maintain glucose uptake in blastocysts grown in diabetic mothers.
15	23568554	The transcription factor cAMP responsive element-binding protein (CREB) and activating transcription factors (ATFs) are downstream components of the insulin/IGF cascade, playing crucial roles in maintaining cell viability and embryo survival.
16	23568554	One of the CREB target genes is adiponectin, which acts synergistically with insulin.
17	23568554	We have studied the CREB-ATF-adiponectin network in rabbit preimplantation development in vivo and in vitro.
18	23568554	From the blastocyst stage onwards, CREB and ATF1, ATF3, and ATF4 are present with increasing expression for CREB, ATF1, and ATF3 during gastrulation and with a dominant expression in the embryoblast (EB).
19	23568554	In vitro stimulation with insulin and IGF-I reduced CREB and ATF1 transcripts by approximately 50%, whereas CREB phosphorylation was increased.
20	23568554	Activation of CREB was accompanied by subsequent reduction in adiponectin and adiponectin receptor (adipoR)1 expression.
21	23568554	Analysis of embryonic adipoRs showed an increased expression of adipoR1 and no changes in adipoR2 transcription.
22	23568554	We conclude that the transcription factors CREB and ATFs vitally participate in embryo-maternal cross talk before implantation in a cell lineage-specific manner.
23	23568554	Embryonic CREB/ATFs act as insulin/IGF sensors.
24	23568554	Lack of insulin is compensated by a CREB-mediated adiponectin expression, which may maintain glucose uptake in blastocysts grown in diabetic mothers.
25	23571712	GLP-1(28-36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro.
26	23571712	An in vitro investigation revealed that GLP-1(28-36)amide stimulates β-catenin (β-cat) Ser(675) phosphorylation in both the clonal INS-1 cell line and rat primary pancreatic islet cells.
27	23571712	GLP-1(28-36)amide was also shown to increase cellular cAMP levels, PKA enzymatic activity, and cAMP response element-binding protein (CREB) and cyclic AMP-dependent transcription factor-1 (ATF-1) phosphorylation.
28	23571712	Furthermore, GLP-1(28-36)amide treatment enhanced islet insulin secretion and increased the growth of INS-1 cells, which was associated with increased cyclin D1 expression.
29	23571712	Finally, PKA inhibition attenuated the effect of GLP-1(28-36)amide on β-cat Ser(675) phosphorylation and cyclin D1 expression in the INS-1 cell line.
30	23571712	Our observations suggest that GLP-1(28-36)amide may exert its effect through the PKA/β-catenin signaling pathway.