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Gene Information
Gene symbol: ATG16L1
Gene name: autophagy related 16-like 1 (S. cerevisiae)
HGNC ID: 21498
Synonyms: WDR30, FLJ10035, ATG16A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL23A | 1 hits |
| 2 | IL23R | 1 hits |
| 3 | IRGM | 1 hits |
| 4 | NOD2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18366306 | The most consistently and strongly associated variants have been in the CARD15, the interleukin 23 receptor (IL23R) and autophagy-related 16-like 1 (ATG16L1) genes. |
| 2 | 21300624 | Amongst these are multiple genes involved in IL23/Th17 signalling (IL23R, IL12B, JAK2, TYK2 and STAT3), IL10, IL1R2, REL, CARD9, NKX2.3, ICOSLG, PRDM1, SMAD3 and ORMDL3. |
| 3 | 21300624 | For Crohn's disease, defective processing of intracellular bacteria has become a central theme, following gene discoveries in autophagy and innate immunity (associations with NOD2, IRGM, ATG16L1 are specific to Crohn's disease). |
| 4 | 21300624 | Genetic evidence has also demonstrated the importance of barrier function to the development of ulcerative colitis (HNF4A, LAMB1, CDH1 and GNA12). |
| 5 | 21530739 | The immune system continuously monitors resident microbiota and utilizes constitutive antimicrobial mechanisms to maintain immune homeostasis. associations between IBD and genes that regulate microbial recognition and innate immune pathways, such as nucleotide oligomerization domain 2 (Nod2), genes that control autophagy (eg, ATG16L1, IRGM), and genes in the interleukin-23-T helper cell 17 pathway indicate the important roles of host-microbe interactions in regulating intestinal immune homeostasis. |