Ignet

Gene Information

Gene symbol: ATR

Gene name: ataxia telangiectasia and Rad3 related

HGNC ID: 882

Synonyms: FRP1, SCKL, SCKL1, MEC1

Related Genes

#	Gene Symbol	Number of hits
1	ATM	1 hits
2	CHEK1	1 hits
3	CHEK2	1 hits
4	H2AFX	1 hits
5	PIK3CA	1 hits
6	PIK3CG	1 hits
7	TP53	1 hits

Related Sentences

#	PMID	Sentence
1	15187252	The checkpoint kinase Chk2 is activated in response to DNA damage through pathways requiring protein kinases ATM and/or ATR.
2	18032786	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.
3	18032786	We show that specific inhibition of iPLA(2) induces a time dependent phosphorylation of Ser15 in p53 in the absence of DNA damage.
4	18032786	This phosphorylation requires the kinase ataxia-telangiectasia and Rad-3-related (ATR) but not the ataxia-telangiectasia-mutated (ATM) kinase.
5	18032786	We further demonstrate that the PCs with linoleic acid in their sn-2 position (18:2n6) induce phosphorylation of Ser15 in p53 in an ATR-dependent manner.
6	18032786	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.
7	18032786	We show that specific inhibition of iPLA(2) induces a time dependent phosphorylation of Ser15 in p53 in the absence of DNA damage.
8	18032786	This phosphorylation requires the kinase ataxia-telangiectasia and Rad-3-related (ATR) but not the ataxia-telangiectasia-mutated (ATM) kinase.
9	18032786	We further demonstrate that the PCs with linoleic acid in their sn-2 position (18:2n6) induce phosphorylation of Ser15 in p53 in an ATR-dependent manner.
10	18032786	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.
11	18032786	We show that specific inhibition of iPLA(2) induces a time dependent phosphorylation of Ser15 in p53 in the absence of DNA damage.
12	18032786	This phosphorylation requires the kinase ataxia-telangiectasia and Rad-3-related (ATR) but not the ataxia-telangiectasia-mutated (ATM) kinase.
13	18032786	We further demonstrate that the PCs with linoleic acid in their sn-2 position (18:2n6) induce phosphorylation of Ser15 in p53 in an ATR-dependent manner.
14	18543256	Cell cycle arrest is mediated by ATR kinase and results in phosphorylation of Chk1 and SMC1.
15	18543256	Thus, MMR can act as a direct sensor of FdU-mediated DNA lesions eliciting cell cycle arrest via the ATR/Chk1 pathway.
16	19710035	ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.
17	19710035	We have previously shown that the ATM and Rad3-related (ATR) checkpoint kinase protects the genome against one type of repeat expansion in a FX premutation mouse model.
18	19710035	However, our data suggest that the ATM-sensitive mechanism is different from the ATR-sensitive one.
19	19710035	Our data thus support the hypothesis that two different mechanisms of FX repeat expansion exist, an ATR-sensitive mechanism seen on maternal transmission and an ATM-sensitive mechanism that shows a male expansion bias.
20	19710035	ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.
21	19710035	We have previously shown that the ATM and Rad3-related (ATR) checkpoint kinase protects the genome against one type of repeat expansion in a FX premutation mouse model.
22	19710035	However, our data suggest that the ATM-sensitive mechanism is different from the ATR-sensitive one.
23	19710035	Our data thus support the hypothesis that two different mechanisms of FX repeat expansion exist, an ATR-sensitive mechanism seen on maternal transmission and an ATM-sensitive mechanism that shows a male expansion bias.
24	19710035	ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.
25	19710035	We have previously shown that the ATM and Rad3-related (ATR) checkpoint kinase protects the genome against one type of repeat expansion in a FX premutation mouse model.
26	19710035	However, our data suggest that the ATM-sensitive mechanism is different from the ATR-sensitive one.
27	19710035	Our data thus support the hypothesis that two different mechanisms of FX repeat expansion exist, an ATR-sensitive mechanism seen on maternal transmission and an ATM-sensitive mechanism that shows a male expansion bias.
28	19710035	ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.
29	19710035	We have previously shown that the ATM and Rad3-related (ATR) checkpoint kinase protects the genome against one type of repeat expansion in a FX premutation mouse model.
30	19710035	However, our data suggest that the ATM-sensitive mechanism is different from the ATR-sensitive one.
31	19710035	Our data thus support the hypothesis that two different mechanisms of FX repeat expansion exist, an ATR-sensitive mechanism seen on maternal transmission and an ATM-sensitive mechanism that shows a male expansion bias.
32	20372103	An early response to the induction of DSBs is phosphorylation of the H2A histone variant, H2AX, at the serine-139 residue, in the highly conserved C-terminal SQEY motif, forming gammaH2AX(1).
33	20372103	Following induction of DSBs, H2AX is rapidly phosphorylated by the phosphatidyl-inosito 3-kinase (PIKK) family of proteins, ataxia telangiectasia mutated (ATM), DNA-protein kinase catalytic subunit and ATM and RAD3-related (ATR)(2).
34	20372103	Phosphorylation of H2AX mediated predominantly by ATM spreads to adjacent areas of chromatin, affecting approximately 0.03% of total cellular H2AX per DSB(2,3).
35	20613712	Phosphorylation of the H2A histone variant, H2AX, at the serine-139 residue, in the highly conserved C-terminal SQEY motif, forming gammaH2AX, is an early response to DNA double-strand breaks.
36	20613712	This phosphorylation event is mediated by the phosphatidyl-inosito 3-kinase (PI3K) family of proteins, ataxia telangiectasia mutated (ATM), DNA-protein kinase catalytic subunit and ATM and RAD3-related (ATR).
37	20736911	This phosphorylation of H2AX is mediated by the phosphatidyl-inosito 3-kinase (PI3K) family of proteins, ataxia telangiectasia mutated (ATM), DNA-protein kinase catalytic subunit and ATM and RAD3-related (ATR).