Ignet

Gene Information

Gene symbol: BBC3

Gene name: BCL2 binding component 3

HGNC ID: 17868

Synonyms: JFY1, PUMA

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	ATF3	1 hits
3	BAK1	1 hits
4	BAX	1 hits
5	BCL2	1 hits
6	BCL2L1	1 hits
7	BCL2L11	1 hits
8	EIF2AK3	1 hits
9	FOXO3	1 hits
10	HRK	1 hits
11	MCL1	1 hits
12	NOX4	1 hits
13	PMAIP1	1 hits
14	TNFRSF10A	1 hits
15	TNFRSF10B	1 hits
16	TNFSF10	1 hits
17	TP53	1 hits
18	TRIB3	1 hits

Related Sentences

#	PMID	Sentence
1	17569614	Resveratrol induces apoptosis by up-regulating the expression of Bax, Bak, PUMA, Noxa, Bim, p53, TRAIL, TRAIL-R1/DR4 and TRAIL-R2/DR5 and simultaneously down-regulating the expression of Bcl-2, Bcl-XL, Mcl-1 and survivin.
2	17569614	Resveratrol causes growth arrest at G1 and G1/S phases of cell cycle by inducing the expression of CDK inhibitors p21/WAF1/CIP1 and p27/KIP1.
3	21937453	Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
4	21937453	Here we clarify the molecular mechanism of β-cell death triggered by the pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-γ.
5	21937453	The combination of TNF-α + IFN-γ induced DP5, p53 up-regulated modulator of apoptosis (PUMA), and Bim expression in human islets and rodent β-cells.
6	21937453	DP5 and PUMA inactivation by RNA interference partially protected against TNF-α + IFN-γ-induced β-cell apoptosis.
7	21937453	Bim expression was transcriptionally regulated by STAT1, and its activation triggered cleavage of caspases.
8	21937453	Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
9	21937453	Here we clarify the molecular mechanism of β-cell death triggered by the pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-γ.
10	21937453	The combination of TNF-α + IFN-γ induced DP5, p53 up-regulated modulator of apoptosis (PUMA), and Bim expression in human islets and rodent β-cells.
11	21937453	DP5 and PUMA inactivation by RNA interference partially protected against TNF-α + IFN-γ-induced β-cell apoptosis.
12	21937453	Bim expression was transcriptionally regulated by STAT1, and its activation triggered cleavage of caspases.
13	22046379	Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway.
14	22046379	Further analysis of effects of ATF3 knockdown on these targets revealed that stress-induced ATF3 regulates genes in metabolic pathways, cell cycle, apoptosis, cell adhesion, and signalling including insulin, p53, Wnt, and VEGF pathways.
15	22046379	Cancer-associated ATF3 is involved in regulation of distinct sets of genes in processes such as calcium signalling, Wnt, p53 and diabetes pathways.
16	22046379	Notably, stress-induced ATF3 binds to 40% of p53 targets and activates pro-apoptotic genes such as TNFRSF10B/DR5 and BBC3/PUMA.
17	22046379	Cancer-associated ATF3, by contrast, represses these pro-apoptotic genes in addition to CDKN1A/p21.
18	22046379	Taken together, our data reveal an extensive network of stress-inducible transcription factors and demonstrate that ATF3 has opposing, cell context-dependent effects on p53 target genes in DNA damage response and cancer development.
19	22711600	The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.
20	22773666	Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.
21	22773666	By microarray analysis, we identified a palmitate-triggered ER stress gene expression signature and the induction of the BH3-only proteins death protein 5 (DP5) and p53-upregulated modulator of apoptosis (PUMA).
22	22773666	Knockdown of either protein reduced cytochrome c release, caspase-3 activation, and apoptosis in rat and human β-cells.
23	22773666	DP5 induction depends on inositol-requiring enzyme 1 (IRE1)-dependent c-Jun NH₂-terminal kinase and PKR-like ER kinase (PERK)-induced activating transcription factor (ATF3) binding to its promoter.
24	22773666	PUMA expression is also PERK/ATF3-dependent, through tribbles 3 (TRB3)-regulated AKT inhibition and FoxO3a activation.
25	22773666	Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.
26	22773666	By microarray analysis, we identified a palmitate-triggered ER stress gene expression signature and the induction of the BH3-only proteins death protein 5 (DP5) and p53-upregulated modulator of apoptosis (PUMA).
27	22773666	Knockdown of either protein reduced cytochrome c release, caspase-3 activation, and apoptosis in rat and human β-cells.
28	22773666	DP5 induction depends on inositol-requiring enzyme 1 (IRE1)-dependent c-Jun NH₂-terminal kinase and PKR-like ER kinase (PERK)-induced activating transcription factor (ATF3) binding to its promoter.
29	22773666	PUMA expression is also PERK/ATF3-dependent, through tribbles 3 (TRB3)-regulated AKT inhibition and FoxO3a activation.