Ignet

Gene Information

Gene symbol: BBS7

Gene name: Bardet-Biedl syndrome 7

HGNC ID: 18758

Synonyms: FLJ10715, BBS2L1

Related Genes

#	Gene Symbol	Number of hits
1	ARL6	1 hits
2	BBS1	1 hits
3	BBS10	1 hits
4	BBS12	1 hits
5	BBS2	1 hits
6	BBS4	1 hits
7	BBS5	1 hits
8	CCT	1 hits
9	HSPD1	1 hits
10	IFT88	1 hits
11	MARVELD2	1 hits
12	MKKS	1 hits
13	TTC8	1 hits

Related Sentences

#	PMID	Sentence
1	15155861	The BBS6 gene is predicted to code for a protein with sequence similarity to the chaperonin family of proteins.
2	15155861	The predicted BBS1, BBS2, BBS4, BBS7, and BBS8 gene products do not seem to be molecular chaperones, on the basis of a lack of sequence similarity to the chaperonin family of proteins.
3	15155861	The identification of BBS8 suggests a possible role in cilia function for BBS gene products.
4	15231740	Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
5	15231740	Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia.
6	15231740	Importantly, we demonstrate that BBS-7 and BBS-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris and CHE-11, and to a notably lesser extent, CHE-2.
7	15231740	Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
8	15231740	Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia.
9	15231740	Importantly, we demonstrate that BBS-7 and BBS-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris and CHE-11, and to a notably lesser extent, CHE-2.
10	15231740	Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
11	15231740	Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia.
12	15231740	Importantly, we demonstrate that BBS-7 and BBS-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris and CHE-11, and to a notably lesser extent, CHE-2.
13	15666242	A mutation of the BBS1 gene on chromosome 11q13 is observed in 30%-40% of BBS cases.
14	15666242	In six cases, we identified a recessive mutation in a BBS gene (three in BBS2, two in BBS4, and one in BBS6).
15	15666242	No BBS1, BBS3, BBS5, BBS7, or BBS8 mutations were identified in our series.
16	15666242	These results suggest that the antenatal presentation of BBS may mimic Meckel syndrome.
17	22500027	To date, 16 BBS genes have been reported, seven of which (BBS1, 2, 4, 5, 7, 8, and 9) code for proteins that form a complex known as the BBSome.
18	22500027	Three additional BBS genes (BBS6, BBS10, and BBS12) have homology to type II chaperonins and interact with CCT/TRiC proteins and BBS7 to form a complex termed the BBS-chaperonin complex.
19	22500027	By characterizing BBSome assembly intermediates, we show that the BBS-chaperonin complex plays a role in BBS7 stability.
20	22500027	BBS7 interacts with BBS2 and becomes part of a BBS7-BBS2-BBS9 assembly intermediate referred to as the BBSome core complex because it forms the core of the BBSome.
21	22500027	BBS1, BBS5, BBS8, and finally BBS4 are added to the BBSome core to form the complete BBSome.
22	22500027	To date, 16 BBS genes have been reported, seven of which (BBS1, 2, 4, 5, 7, 8, and 9) code for proteins that form a complex known as the BBSome.
23	22500027	Three additional BBS genes (BBS6, BBS10, and BBS12) have homology to type II chaperonins and interact with CCT/TRiC proteins and BBS7 to form a complex termed the BBS-chaperonin complex.
24	22500027	By characterizing BBSome assembly intermediates, we show that the BBS-chaperonin complex plays a role in BBS7 stability.
25	22500027	BBS7 interacts with BBS2 and becomes part of a BBS7-BBS2-BBS9 assembly intermediate referred to as the BBSome core complex because it forms the core of the BBSome.
26	22500027	BBS1, BBS5, BBS8, and finally BBS4 are added to the BBSome core to form the complete BBSome.
27	22500027	To date, 16 BBS genes have been reported, seven of which (BBS1, 2, 4, 5, 7, 8, and 9) code for proteins that form a complex known as the BBSome.
28	22500027	Three additional BBS genes (BBS6, BBS10, and BBS12) have homology to type II chaperonins and interact with CCT/TRiC proteins and BBS7 to form a complex termed the BBS-chaperonin complex.
29	22500027	By characterizing BBSome assembly intermediates, we show that the BBS-chaperonin complex plays a role in BBS7 stability.
30	22500027	BBS7 interacts with BBS2 and becomes part of a BBS7-BBS2-BBS9 assembly intermediate referred to as the BBSome core complex because it forms the core of the BBSome.
31	22500027	BBS1, BBS5, BBS8, and finally BBS4 are added to the BBSome core to form the complete BBSome.