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Gene Information
Gene symbol: C3orf39
Gene name: chromosome 3 open reading frame 39
HGNC ID: 25902
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABO | 1 hits |
| 2 | B4GALNT1 | 1 hits |
| 3 | B4GALNT2 | 1 hits |
| 4 | COL1A1 | 1 hits |
| 5 | INS | 1 hits |
| 6 | LGALS1 | 1 hits |
| 7 | MGAT4A | 1 hits |
| 8 | SLC2A2 | 1 hits |
| 9 | ST3GAL5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 601754 | Collagen-induced platelet aggregation and collagen glycosyltransferase activity in diabetic patients. |
| 2 | 6132847 | There were no significant differences between the diabetic and control rat liver microsomes in the activities of UDP N-acetylglucosamine pyrophosphatase, UDP galactose pyrophosphatase, or CMP sialic acid phosphatase. |
| 3 | 6132847 | These results are discussed in relation to our previously reported alterations in glycosyltransferase activities, and plasma membrane glycoprotein composition in the livers of rats made insulin-resistant by a carbohydrate-free, high-fat diet and to the observation of Carter and his colleagues (FEBS Lett. 1979; 104:389-92.) that streptozotocin diabetes alters the glycoprotein composition of rat liver plasma membranes. |
| 4 | 7558008 | beta-1,4-N-Acetylgalactosaminyltransferase involved in ganglioside synthesis: cDNA sequence, expression, and chromosome mapping of the mouse gene. |
| 5 | 7558008 | beta-1,4-N-Acetylgalactosaminyltransferase (EC 2.4.1.92; GalNAc-T) is a glycosyltransferase involved in the synthesis of gangliosides GM2 and GD2 as well as glycolipid GA2. |
| 6 | 10198028 | The pseudooligosaccharide acarbose is a potent inhibitor of amylases, glucosidases, and cyclodextrin glycosyltransferase and is clinically used for the treatment of so-called type II or insulin-independent diabetes. |
| 7 | 15710896 | To determine the role of ganglioside synthesis within the CNS, mice carrying null mutations in two critical ganglioside-specific glycosyltransferase genes, Siat9 (encoding GM3 synthase) and Galgt1 (encoding GM2 synthase), were generated. |
| 8 | 16377570 | Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. |
| 9 | 16377570 | We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface by constructing a cell-type- and glycoprotein-specific N-glycan ligand for pancreatic lectin receptors. |
| 10 | 21841783 | Elevated concentrations of free fatty acids caused nuclear exclusion and reduced expression of the transcription factors FOXA2 and HNF1A in beta cells. |
| 11 | 21841783 | This resulted in a deficit of GnT-4a glycosyltransferase expression in beta cells that produced signs of metabolic disease, including hyperglycemia, impaired glucose tolerance, hyperinsulinemia, hepatic steatosis and diminished insulin action in muscle and adipose tissues. |
| 12 | 23548572 | The glucose transporter isoform, GLUT2, -mediated glucose sensing is essential for maintaining normal glucose-stimulated insulin secretion in pancreatic beta cells. |
| 13 | 23548572 | We previously reported that GnT-IVa glycosyltransferase is required for the production of an N-glycan structure that acts as a ligand for galectins to form the glycan-galectin lattice that maintains the stable cell surface expression of GLUT2, and cellular glucose transport activity, although the functional relevance of the N-glycosylation of GLUT2 to its membrane sub-domain distribution is not fully understood. |
| 14 | 23548572 | In the present study, we demonstrated that disruption of the GLUT2 N-glycan-galectin lattice by the genetic inactivation of GnT-IVa, or by treatment of pancreatic beta cells with competitive glycan mimetics, induced the re-distribution of GLUT2 into the lipid-raft microdomain. |
| 15 | 23548572 | This subsequently resulted in the binding of Stomatin to GLUT2 and an attenuation of cellular glucose transport activity. |
| 16 | 23548572 | Moreover, disruption of the lipid-raft microdomain by treatment with methyl-β-cyclodextrin caused the GLUT2 to be released from lipid-rafts and reactivation of the cellular glucose transport activity in GnT-IVa deficient beta cells. |
| 17 | 23548572 | These results indicate that the membrane sub-domain distribution of GLUT2 is associated with the glucose transport activity of beta cells, in which the GnT-IVa-dependent formation of the N-glycan-galectin lattice plays an important role. |