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Gene Information
Gene symbol: CADPS
Gene name: Ca++-dependent secretion activator
HGNC ID: 1426
Synonyms: CAPS, KIAA1121, CAPS1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MEFV | 1 hits |
| 2 | NLRP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20493414 | Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome. |
| 2 | 20493414 | NLRP3 inflammasome activation and IL-1beta secretion have recently emerged as a central mechanism in the pathogenesis of disease. |
| 3 | 20493414 | Genetically defined syndromes like cryopyrin-associated periodic syndromes (CAPS, cryopyrinopathies) and familial Mediterranean fever (FMF) or diseases associated with NLRP3 activation by danger signals like gout, pseudogout, Alzheimer's disease or type 2 diabetes are included in this group of diseases. |
| 4 | 20493414 | The contribution of anakinra, a recombinant, nonglycosylated human IL-1 receptor antagonist, in both the identification and treatment of such syndromes was considerable. |
| 5 | 20493414 | Recently, rilonacept, a long-acting IL-1 receptor fusion protein, and canakinumab, a fully humanized anti-IL-1beta monoclonal antibody, have been developed, with the intention to further extent IL-1beta inhibition treatment strategies to a broader spectrum of disorders beyond the characterized autoinflammatory syndromes, offering a more favorable administration profile. |