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Gene Information
Gene symbol: CALCB
Gene name: calcitonin-related polypeptide beta
HGNC ID: 1438
Synonyms: FLJ30166, CGRP-II
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CALCA | 1 hits |
| 2 | GAST | 1 hits |
| 3 | IAPP | 1 hits |
| 4 | INS | 1 hits |
| 5 | POMC | 1 hits |
| 6 | PPY2 | 1 hits |
| 7 | VIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2639135 | Recently, islet- or insulinoma-amyloid polypeptide (IAPP) was isolated as a major constituent of amyloid present in human insulinoma and in pancreatic islet amyloid in noninsulin-dependent diabetes mellitus. |
| 2 | 2639135 | IAPP shows 46% amino acid sequence homology with human CGRP-II. |
| 3 | 8606627 | Increased levels of secondary hormones, such as gastrin (4 patients), vasoactive intestinal peptide (1 patient), serotonin (5 patients), insulin (6 patients, clinically significant in 1 only), human pancreatic polypeptide (2 patients), calcitonin (2 patients) and adrenocorticotropic hormone (2 patients), contributed to clinical symptoms leading to the diagnosis of an islet cell tumor before the onset of the full glucagonoma syndrome in 2 patients. |
| 4 | 9353797 | More recently, islet amyloid polypeptide or amylin, and adrenomedullin were isolated from human insulinoma and pheochromocytoma respectively, and revealed between 25 and 50% sequence homology with CGRP. |
| 5 | 9353797 | Based upon the differential biological activity of various CGRP analogs, the CGRP receptors have been classified in two major classes, namely the CGRP1 and CGRP2 subtypes. |
| 6 | 9353797 | Indeed, modulation of adenylate cyclase activity following receptor activation has been reported for CGRP, amylin and adrenomedullin. |
| 7 | 9353797 | The cloning of various calcitonin and most recently of CGRP1 and adrenomedullin receptors was reported and revealed structural similarities but also significant differences to other members of the G protein-coupled receptors. |
| 8 | 14532375 | Based on the differential biological activities of various CGRP analogs, the CGRP receptors have been classified into CGRP1 and CGRP2. |
| 9 | 14532375 | CGRP receptor belongs to the calcitonin receptor like receptor (CRLR) family of G-protein-coupled receptors and has been shown to require a single transmembrane domain protein called receptor activity modifying protein-1 (RAMP1) for its functional expression as well as activity. |
| 10 | 16804794 | After removal of the pancreatic tumor, clinical symptoms resolved and biochemical markers normalized (serum insulin, 14.9 microU/ml; C-peptide, 3.0 ng/ml; calcitonin, 2.9 pg/ml) confirming the causal relationship between insulinoma and markedly increased serum calcitonin levels. |