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Gene Information

Gene symbol: CAMK1

Gene name: calcium/calmodulin-dependent protein kinase I

HGNC ID: 1459

Synonyms: CaMKI

Related Genes

#	Gene Symbol	Number of hits
1	CAMK2G	1 hits
2	CAMKK2	1 hits

Related Sentences

#	PMID	Sentence
1	10673339	While CaMKII has been implicated in learning and memory, the biological role of the other multifunctional CaM kinases, CaMKI and CaMKIV, is largely unknown.
2	17287469	Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.
3	17287469	Studies in nonmuscle cells have demonstrated that Ca(2+)/calmodulin-dependent protein kinase kinases (CaMKKs) are upstream regulators of AMP-activated protein kinase (AMPK) and Akt.
4	17287469	In skeletal muscle, activation of AMPK and Akt has been implicated in the regulation of glucose uptake.
5	17287469	The objective of this study was to determine whether CaMKKalpha regulates skeletal muscle glucose uptake, and whether it is dependent on AMPK and/or Akt activation.
6	17287469	After 2 weeks, caCaMKKalpha was robustly expressed and increased CaMKI (Thr(177/180)) phosphorylation, a known CaMKK substrate.
7	17287469	Akt (Thr(308)) phosphorylation was not altered by CaMKKalpha, and caCaMKKalpha plus insulin stimulation did not increase the insulin-induced phosphorylation of Akt (Thr(308)).
8	17287469	Collectively, these results implicate CaMKKalpha in the regulation of skeletal muscle glucose uptake independent of AMPK and Akt activation.