Ignet

Gene Information

Gene symbol: CAP1

Gene name: CAP, adenylate cyclase-associated protein 1 (yeast)

HGNC ID: 20040

Synonyms: CAP

Related Genes

#	Gene Symbol	Number of hits
1	ACE	1 hits
2	ADIPOQ	1 hits
3	AKT1	1 hits
4	ALB	1 hits
5	APLP2	1 hits
6	CALCA	1 hits
7	CBL	1 hits
8	CRYGD	1 hits
9	CYCS	1 hits
10	HBB	1 hits
11	HLA-A	1 hits
12	IAPP	1 hits
13	INS	1 hits
14	PPARA	1 hits
15	PPARG	1 hits
16	RAPGEF1	1 hits
17	RARB	1 hits
18	RHOQ	1 hits
19	RXRA	1 hits
20	SMC3	1 hits

Related Sentences

#	PMID	Sentence
1	696250	CAP, HCS and urinary oestriol assays in diabetic pregnancy.
2	696250	The value of serial estimations of plasma CAP, HCS and urinary oestriol assays in pregnancies complicated with diabetes has been studied.
3	696250	It is concluded that the levels of CAP, HCS and urinary oesteriol excretion in diabetic pregnancies are comparable to those found in normal pregnancy.
4	696250	CAP, HCS and urinary oestriol assays in diabetic pregnancy.
5	696250	The value of serial estimations of plasma CAP, HCS and urinary oestriol assays in pregnancies complicated with diabetes has been studied.
6	696250	It is concluded that the levels of CAP, HCS and urinary oesteriol excretion in diabetic pregnancies are comparable to those found in normal pregnancy.
7	696250	CAP, HCS and urinary oestriol assays in diabetic pregnancy.
8	696250	The value of serial estimations of plasma CAP, HCS and urinary oestriol assays in pregnancies complicated with diabetes has been studied.
9	696250	It is concluded that the levels of CAP, HCS and urinary oesteriol excretion in diabetic pregnancies are comparable to those found in normal pregnancy.
10	2249605	Among all diabetics, 56.6% was noninsulin-dependent (NIDDM) and 26.4% insulin-dependent (IDDM).
11	2249605	Insulin treatment was frequent in CAP (52.2%) and CCP (61.7%), but less in other CP (27.5%).
12	2249605	The prevalence of complications, including macroangiopathy tended to be higher in CAP and CCP (40.3 and 56.9%) than in other CP (31.4%).
13	2249605	Among all diabetics, 56.6% was noninsulin-dependent (NIDDM) and 26.4% insulin-dependent (IDDM).
14	2249605	Insulin treatment was frequent in CAP (52.2%) and CCP (61.7%), but less in other CP (27.5%).
15	2249605	The prevalence of complications, including macroangiopathy tended to be higher in CAP and CCP (40.3 and 56.9%) than in other CP (31.4%).
16	2454032	Rat CGRP and human CGRP were equipotent in opposing contraction with a half-maximal effect produced by 0.1 nM, but rat calcitonin-adjacent peptide (rat CAP) and human calcitonin had no effect.
17	2454032	Rat CGRP and human CGRP were equipotent for stimulating cAMP, but rat CAP and human calcitonin had no effect.
18	2454032	Rat CGRP and human CGRP were equipotent at inhibiting binding of 125I-CGRP and rat CAP, and human calcitonin did not inhibit binding.
19	2454032	Rat CGRP and human CGRP were equipotent in opposing contraction with a half-maximal effect produced by 0.1 nM, but rat calcitonin-adjacent peptide (rat CAP) and human calcitonin had no effect.
20	2454032	Rat CGRP and human CGRP were equipotent for stimulating cAMP, but rat CAP and human calcitonin had no effect.
21	2454032	Rat CGRP and human CGRP were equipotent at inhibiting binding of 125I-CGRP and rat CAP, and human calcitonin did not inhibit binding.
22	2454032	Rat CGRP and human CGRP were equipotent in opposing contraction with a half-maximal effect produced by 0.1 nM, but rat calcitonin-adjacent peptide (rat CAP) and human calcitonin had no effect.
23	2454032	Rat CGRP and human CGRP were equipotent for stimulating cAMP, but rat CAP and human calcitonin had no effect.
24	2454032	Rat CGRP and human CGRP were equipotent at inhibiting binding of 125I-CGRP and rat CAP, and human calcitonin did not inhibit binding.
25	2491997	Incubation of freshly isolated islets from CAP (RT1c) and LEW (RT1l) rats with OX18, an MHC class I antibody, showed strong positive reactivity in macrophages and/or dendritic-like cells (M0-DCs) and vascular endothelial cells (VEs) and a comparatively weaker reactivity in endocrine alpha-, beta-, and delta-cells.
26	2491997	Four days of in vitro culture in combination with a high concentration of glucose and interferon-gamma induced strong enhancement of MHC class I structures and, to a lesser extent, class II structures on beta-cells.
27	7603292	The effects of non-insulin-dependent diabetes mellitus (NIDDM) were investigated on the reactivity of human internal mammary artery (IMA) and saphenous vein (SV) rings obtained from coronary artery patients (CAP) undergoing coronary artery bypass surgery.
28	8444082	The aim of this study was to assess the residual beta cell function (evaluated by means of the glucagon test) and the mean disposal rate of insulin (with the insulin tolerance test) in 66 CAP patients with or without abnormalities of glucose metabolism and in 19 control subjects.
29	11757805	No significant difference in mortality was found between diabetics and non-diabetics, for either CAP or HAP.
30	11865577	Diabetes develops in more than half of the patients with chronic alcoholic pancreatitis (CAP), mostly due to increasing insulin deficiency.
31	12630035	Elevated fasting plasma level of islet amyloid polypeptide (IAPP) in chronic alcoholic pancreatitis (CAP).
32	12644458	High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells.
33	12644458	Recent studies have indicated that insulin activates endothelial nitric-oxide synthase (eNOS) by protein kinase B (PKB)-mediated phosphorylation at Ser1177 in endothelial cells.
34	12644458	This was accompanied by reduced expression of IRS-2 and attenuated insulin-stimulated recruitment of PI3K to IRS-1 and IRS-2, yet insulin-stimulated PKB activity and phosphorylation of eNOS at Ser1177 were unaffected.
35	12644458	Furthermore, high glucose down-regulated the expression of CAP and Cbl, and insulin-stimulated Cbl phosphorylation, components of an insulin signaling cascade previously characterized in adipocytes.
36	12644458	These data suggest that high glucose specifically inhibits insulin-stimulated NO synthesis and down-regulates some aspects of insulin signaling, including the CAP-Cbl signaling pathway, yet this is not a result of reduced PKB-mediated eNOS phosphorylation at Ser1177.
37	12711303	Among the subtypes, DCAPL3 shows significant homology with CAP, an essential component of glucose transport in insulin signal.
38	12711303	Further binding assay revealed that DCAP binds to not only Axin but also Arrow, and Axin binds to not only GSK3beta but also Arrow.
39	12711303	Moreover, early stage embryos lacking maternal Axin show significant delay of initial glycogen decomposition, and RNAi of Axin in S2 cells revealed quite increase of endogenous glycogen level as well as GSK3beta.
40	12711303	In addition, the interaction among Axin, Arrow, and DCAP implies a possible cross-talk between Wnt signal and insulin signal.
41	14684612	During the clamp, there is no alteration in the expression or activation in the insulin signaling molecules involved in glucose transport through the phosphoinositide 3-kinase/Akt and CAP/Cbl pathways in WAT from MIRKO.
42	14684612	There is a 39.5% increase in serum adiponectin (P < 0.01) without modification in serum leptin, resistin, and TNF-alpha.
43	14684612	There is an accelerated differentiation of small insulin sensitive adipocytes, an increased secretion of the insulin sensitizer adiponectin, and maintenance of leptin sensitivity.
44	16455828	The aim of the present study was to assess whether the use of angiotensin-converting enzyme (ACE) inhibitors is associated with a decreased risk of hospitalisation for community-acquired pneumonia (CAP) in a general, essentially white population.
45	16494846	In adipocytes, the Cbl/CAP dependent signaling pathway has been involved in regulating insulin-stimulated glucose uptake.
46	16494846	Subsequent TC10 activation was detected only in heart and adipose tissue. c-Cbl and CAP gene expression was significantly reduced in the heart tissue of streptozotocin-induced diabetic animals, whereas no change was observed for other components of the pathway.
47	16494846	In leptin-/- obese mice Cbl expression in heart and adipose tissue was maintained, although insulin-mediated Cbl phosphorylation and subsequent TC10 activation were significantly reduced.
48	16494846	In conclusion, our data demonstrate that Cbl/CAP/TC10 insulin signaling pathway is active in cardiac muscle and impaired during obesity and insulin deficiency.
49	16494846	In adipocytes, the Cbl/CAP dependent signaling pathway has been involved in regulating insulin-stimulated glucose uptake.
50	16494846	Subsequent TC10 activation was detected only in heart and adipose tissue. c-Cbl and CAP gene expression was significantly reduced in the heart tissue of streptozotocin-induced diabetic animals, whereas no change was observed for other components of the pathway.
51	16494846	In leptin-/- obese mice Cbl expression in heart and adipose tissue was maintained, although insulin-mediated Cbl phosphorylation and subsequent TC10 activation were significantly reduced.
52	16494846	In conclusion, our data demonstrate that Cbl/CAP/TC10 insulin signaling pathway is active in cardiac muscle and impaired during obesity and insulin deficiency.
53	16494846	In adipocytes, the Cbl/CAP dependent signaling pathway has been involved in regulating insulin-stimulated glucose uptake.
54	16494846	Subsequent TC10 activation was detected only in heart and adipose tissue. c-Cbl and CAP gene expression was significantly reduced in the heart tissue of streptozotocin-induced diabetic animals, whereas no change was observed for other components of the pathway.
55	16494846	In leptin-/- obese mice Cbl expression in heart and adipose tissue was maintained, although insulin-mediated Cbl phosphorylation and subsequent TC10 activation were significantly reduced.
56	16494846	In conclusion, our data demonstrate that Cbl/CAP/TC10 insulin signaling pathway is active in cardiac muscle and impaired during obesity and insulin deficiency.
57	17493948	Age, albumin/creatinine ratio, hemoglobin A1c, diabetes, hypertension, and lipid-lowering therapy were correlated with quantity of CAP in all vascular beds (all p<0.05); no differences in the strength of these relations were noted.
58	17932108	We investigated the effect of the HIV-1 accessory protein viral protein R (Vpr) on the activity of the peroxisome proliferator-activating receptor-gamma (PPARgamma), a key regulator of adipocyte differentiation and tissue insulin sensitivity.
59	17932108	We investigated Vpr interaction with the PPAR/retinoid X receptor (RXR)-binding site of the c-Cbl-associating protein (CAP) gene using the chromatin immunoprecipitation assay as well as the interaction of Vpr and PPARgamma using coimmunoprecipitation.
60	17932108	Vpr suppressed mRNA expression of PPARgamma-responsive genes in undifferentiated 3T3-L1 cells and associated with the PPAR/RXR-binding site located in the promoter region of the CAP gene.
61	17932108	Vpr delivered either by an expression plasmid or as protein added to media suppressed PPARgamma agonist-induced adipocyte differentiation, assessed as lipid accumulation and mRNA expression of the adipocyte differentiation marker adipocyte P2 in 3T3-L1 cells.
62	17932108	We investigated the effect of the HIV-1 accessory protein viral protein R (Vpr) on the activity of the peroxisome proliferator-activating receptor-gamma (PPARgamma), a key regulator of adipocyte differentiation and tissue insulin sensitivity.
63	17932108	We investigated Vpr interaction with the PPAR/retinoid X receptor (RXR)-binding site of the c-Cbl-associating protein (CAP) gene using the chromatin immunoprecipitation assay as well as the interaction of Vpr and PPARgamma using coimmunoprecipitation.
64	17932108	Vpr suppressed mRNA expression of PPARgamma-responsive genes in undifferentiated 3T3-L1 cells and associated with the PPAR/RXR-binding site located in the promoter region of the CAP gene.
65	17932108	Vpr delivered either by an expression plasmid or as protein added to media suppressed PPARgamma agonist-induced adipocyte differentiation, assessed as lipid accumulation and mRNA expression of the adipocyte differentiation marker adipocyte P2 in 3T3-L1 cells.
66	18191060	SNP45 and SNP276 ACDC were genotyped, and B-mode ultrasonography of the carotid arteries was performed to measure carotid intima-media thickness and assess the presence of carotid artery plaques (CAP).
67	18191060	Although there was no significant difference in carotid intima-media thickness according to ACDC genotype, subjects carrying the SNP45 GG genotype had a significantly higher risk of having CAP (odds ratio, 2.468; P = .045) compared with carriers of the T allele after adjustment for possible confounding factors.
68	18191060	This study suggests that the GG genotype at ACDC SNP45 is associated with the presence of CAP and may contribute to atherosclerosis in type 2 diabetes mellitus.
69	18191060	SNP45 and SNP276 ACDC were genotyped, and B-mode ultrasonography of the carotid arteries was performed to measure carotid intima-media thickness and assess the presence of carotid artery plaques (CAP).
70	18191060	Although there was no significant difference in carotid intima-media thickness according to ACDC genotype, subjects carrying the SNP45 GG genotype had a significantly higher risk of having CAP (odds ratio, 2.468; P = .045) compared with carriers of the T allele after adjustment for possible confounding factors.
71	18191060	This study suggests that the GG genotype at ACDC SNP45 is associated with the presence of CAP and may contribute to atherosclerosis in type 2 diabetes mellitus.
72	18191060	SNP45 and SNP276 ACDC were genotyped, and B-mode ultrasonography of the carotid arteries was performed to measure carotid intima-media thickness and assess the presence of carotid artery plaques (CAP).
73	18191060	Although there was no significant difference in carotid intima-media thickness according to ACDC genotype, subjects carrying the SNP45 GG genotype had a significantly higher risk of having CAP (odds ratio, 2.468; P = .045) compared with carriers of the T allele after adjustment for possible confounding factors.
74	18191060	This study suggests that the GG genotype at ACDC SNP45 is associated with the presence of CAP and may contribute to atherosclerosis in type 2 diabetes mellitus.
75	19296421	Different studies have shown that, in comparison with community-acquired pneumonia (CAP) patients, HCAP patients are significantly older, have a higher number of comorbidities (cerebrovascular diseases, congestive heart failure, dementia, and diabetes mellitus) and show worse functional status before admission.
76	19297053	Under the activation of insulin receptors, glucose transporter 4 (Glut4) translocation is regulated by two signal transduction pathways.
77	19297053	These pathways are the PI 3-kinase-dependent pathway and the CAP/TC10 pathway.
78	19297053	The adaptor protein Rap guanine exchange factor 1 (RAPGEF1) also known as C3G is a component of the CAP/TC10 pathway.
79	19297053	Defects in the RAPGEF1 protein may contribute to insulin resistance and type 2 diabetes.
80	19297053	Under the activation of insulin receptors, glucose transporter 4 (Glut4) translocation is regulated by two signal transduction pathways.
81	19297053	These pathways are the PI 3-kinase-dependent pathway and the CAP/TC10 pathway.
82	19297053	The adaptor protein Rap guanine exchange factor 1 (RAPGEF1) also known as C3G is a component of the CAP/TC10 pathway.
83	19297053	Defects in the RAPGEF1 protein may contribute to insulin resistance and type 2 diabetes.