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Gene Information
Gene symbol: CAPN1
Gene name: calpain 1, (mu/I) large subunit
HGNC ID: 1476
Synonyms: muCANP, muCL, CANP, CANPL1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ANKRD23 | 1 hits |
| 2 | CAPN10 | 1 hits |
| 3 | CAPN2 | 1 hits |
| 4 | CAPN3 | 1 hits |
| 5 | CAPN5 | 1 hits |
| 6 | INS | 1 hits |
| 7 | NPPA | 1 hits |
| 8 | NPPC | 1 hits |
| 9 | NPR3 | 1 hits |
| 10 | TTN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11516996 | Overactivation of calpain 1 and calpain 2 (and their small subunit) has long been tied to acute neurological disorders (e.g. stroke and traumatic brain injury) and recently to Alzheimer's disease. |
| 2 | 11516996 | Calpain 10 was recently identified as a susceptibility gene for type 2 diabetes, whereas calpain 9 appears to be a gastric cancer suppressor. |
| 3 | 16904201 | Atrial natriuretic peptide receptor types A (NPR-A) and C (NPR-C) binding properties and functional characteristics in renal glomeruli have been investigated in deoxycorticosterone acetate (DOCA)-treated hypertensive Wistar-Kyoto (WKY) rats and their respective controls. |
| 4 | 16904201 | We found that DOCA administration had no significant effect on the maximum binding capacity or the affinity of renal NPR-A and NPR-C. |
| 5 | 16904201 | Our results indicate that the cAMP production by NPR-C is not altered in DOCA-induced hypertension, since ANP(1-28), CNP(1-22) and C-ANP, which specifically bind to NPR-C, show a similar inhibitory effect on cAMP production stimulated by the physiological agonist histamine in glomeruli from DOCA-treated rats and controls. |
| 6 | 16904201 | Finally, we have found that DOCA-induced hypertension does not modify NPR-A or NPR-C expression in rat glomerular membranes. |
| 7 | 16904201 | These findings indicate that NPR-A and NPR-C binding properties and NPR-C-mediated inhibition of cAMP generation remain unaltered in DOCA-treated rats. |
| 8 | 17150188 | However, high glucose did not significantly alter expression of the two major ubiquitously expressed calpain family members, CAPN1 and CAPN2. |
| 9 | 17151322 | Positional cloning studies mapped T2DM susceptibility to CAPN10, the gene encoding the intracellular cysteine protease, calpain 10. |
| 10 | 17151322 | Here we review recent studies, which in addition to the latter enzyme, have linked calpain 5, calpain 3, and its splice variants, calpain 2 and calpain 1 to T2DM-related metabolic pathways along with T2DM-associated phenotypes, such as obesity and impaired insulin secretion, and T2DM-related complications, such as epithelial dysfunction and diabetic cataract. |
| 11 | 19150862 | In this study, mRNA expression of titin, muscle LIM protein (MLP), cardiac ankyrin repeat protein (CARP), ankyrin repeat domain protein 2 (Ankrd2), diabetes-related ankyrin repeat protein (DARP), and calcium-activated proteinases, calpains, were investigated in human skeletal muscle after fatiguing jumping exercise. |
| 12 | 19150862 | Fatiguing jumping exercise did not change mRNA expression of titin, DARP, calpain 1, or calpain 3. |
| 13 | 19150862 | MLP, Ankrd2 and calpain 2 mRNA levels were increased 2 days postexercise. |
| 14 | 19150862 | Increased mRNA expression of MLP, CARP, and Ankrd2, observed for the first time in human skeletal muscle, may be part of the signaling activated by physical exercise. |
| 15 | 22612451 | Calpain 10 is a ubiquitously expressed mitochondrial and cytosolic Ca(2+)-regulated cysteine protease in which overexpression or knockdown leads to mitochondrial dysfunction and cell death. |
| 16 | 22612451 | Therefore, we created a homology model using the calpain 10 amino acid sequence and calpain 1 3-D structure and docked CYGAK in the active site. |
| 17 | 22612451 | RPTC treated with 10 μM CYGAK-OC for 24 h induced accumulation of ATP synthase β and NDUFB8, two calpain 10 substrates. |