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Gene Information
Gene symbol: CAPN3
Gene name: calpain 3, (p94)
HGNC ID: 1480
Synonyms: CANP3, p94, nCL-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ANKRD23 | 1 hits |
| 2 | CAPN1 | 1 hits |
| 3 | CAPN10 | 1 hits |
| 4 | CAPN2 | 1 hits |
| 5 | CAPN5 | 1 hits |
| 6 | INS | 1 hits |
| 7 | TTN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12075569 | Calpain 3 gene expression in skeletal muscle is associated with body fat content and measures of insulin resistance. |
| 2 | 12843569 | Based on the 3D structures of micro - and m-calpain, molecular functions of p94 in relation to LGMD2A are discussed, with the hope of providing us with some clues to understand calpain functions and its relationships to human diseases. |
| 3 | 15336956 | In two cases, however, the alteration of a member of the calpain family has been clearly identified as being responsible for a human disease: the loss of function of calpain 3 causes limb girdle muscular dystrophy type 2A, and mutations in the gene coding for calpain 10 have been shown to correlate with non-insulin-dependent diabetes. |
| 4 | 15362498 | A number of calpains have been identified in the lens, including calpain 2, calpain 10 and two isozymes of calpain 3: Lp82 and Lp85. |
| 5 | 15362498 | The use of animal hereditary cataract models have suggested that calpain 2 and/or Lp82 may be the major calpains involved in murine cataractogenesis with contributions from calpain 10 and Lp85. |
| 6 | 17151322 | Positional cloning studies mapped T2DM susceptibility to CAPN10, the gene encoding the intracellular cysteine protease, calpain 10. |
| 7 | 17151322 | Here we review recent studies, which in addition to the latter enzyme, have linked calpain 5, calpain 3, and its splice variants, calpain 2 and calpain 1 to T2DM-related metabolic pathways along with T2DM-associated phenotypes, such as obesity and impaired insulin secretion, and T2DM-related complications, such as epithelial dysfunction and diabetic cataract. |
| 8 | 19150862 | In this study, mRNA expression of titin, muscle LIM protein (MLP), cardiac ankyrin repeat protein (CARP), ankyrin repeat domain protein 2 (Ankrd2), diabetes-related ankyrin repeat protein (DARP), and calcium-activated proteinases, calpains, were investigated in human skeletal muscle after fatiguing jumping exercise. |
| 9 | 19150862 | Fatiguing jumping exercise did not change mRNA expression of titin, DARP, calpain 1, or calpain 3. |
| 10 | 19150862 | MLP, Ankrd2 and calpain 2 mRNA levels were increased 2 days postexercise. |
| 11 | 19150862 | Increased mRNA expression of MLP, CARP, and Ankrd2, observed for the first time in human skeletal muscle, may be part of the signaling activated by physical exercise. |