Ignet

Gene Information

Gene symbol: CASP2

Gene name: caspase 2, apoptosis-related cysteine peptidase

HGNC ID: 1503

Synonyms: ICH1, PPP1R57

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	AIFM1	1 hits
3	AKT1	1 hits
4	BAX	1 hits
5	BCL2	1 hits
6	CASP3	1 hits
7	CASP7	1 hits
8	CCND1	1 hits
9	CYCS	1 hits
10	JUP	1 hits
11	MAPK8	1 hits
12	NPY	1 hits
13	PARP1	1 hits
14	PRSS1	1 hits
15	SH2D1A	1 hits
16	TRB	1 hits

Related Sentences

#	PMID	Sentence
1	9159148	Western blot analyses using antibodies directed against specific apoptotic proteases (interleukin 1beta converting enzyme, Nedd-2, and Apopain/CPP 32) confirmed these findings.
2	10051319	Secondly, caspase-2 maps close to Tcrb on mouse Chromosome (Chr) 6, while Lyp is closely linked to Tcrb on the homologous rat Chr 4.
3	10051319	Since Lyp maps distally to D4Mit5, between markers D4Rat75 and Npy, we exclude caspase-2 as a candidate gene for Lyp.
4	10051319	Secondly, caspase-2 maps close to Tcrb on mouse Chromosome (Chr) 6, while Lyp is closely linked to Tcrb on the homologous rat Chr 4.
5	10051319	Since Lyp maps distally to D4Mit5, between markers D4Rat75 and Npy, we exclude caspase-2 as a candidate gene for Lyp.
6	10777670	Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene.
7	10777670	In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1.
8	10777670	This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY.
9	10777670	We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35.
10	10777670	Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene.
11	10777670	In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1.
12	10777670	This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY.
13	10777670	We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35.
14	10777670	Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene.
15	10777670	In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1.
16	10777670	This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY.
17	10777670	We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35.
18	12488362	Serum removal caused, over a 36-h period, oxidative stress and an early impairment of mitochondrial function, as revealed by increased superoxide production and markedly reduced mitochondrial membrane potential, but a lack of cytochrome c and apoptosis-inducing factor release in the cytosol.
19	12488362	The fatty acids palmitate and oleate considerably accelerated the apoptosis process in serum-starved cells, as revealed by fluorescence-activated cell sorting analysis, morphological changes, chromatin condensation, DNA laddering, poly(ADP-ribose) polymerase cleavage, cytochrome c and apoptosis-inducing factor release, and increased levels of Bax and cytosolic caspase-2.
20	21538476	However, caspase-2 deficiency attenuated diabetes-induced bone marrow adiposity and adipocyte gene expression.
21	23054864	The results showed breast cancer cells respond in a diverse manner to LiCl, i.e., at lower concentrations (1, 5, and 10 mM), LiCl induces cell survival by inhibiting apoptosis through regulation of GSK-3β, caspase-2, Bax, and cleaved caspase-7 and by activating anti-apoptotic proteins (Akt, β-catenin, Bcl-2, and cyclin D1).
22	23466956	Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells.