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Gene Information
Gene symbol: CASP4
Gene name: caspase 4, apoptosis-related cysteine peptidase
HGNC ID: 1505
Synonyms: ICE(rel)II, ICH-2, TX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DDIT3 | 1 hits |
| 2 | HSPA5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18006837 | The underlying mechanism of this antitumor effect involves the potent stimulation of the endoplasmic reticulum (ER) stress response (ESR), as indicated by increased expression of two ESR markers, GRP78 and CHOP, and activation of ESR-associated caspase-4. |
| 2 | 18006837 | Induction of ESR seems to play a central role in PI-induced cell death because small interfering RNA-mediated knockdown of the protective ER chaperone GRP78 sensitizes cells; whereas knockdown of proapoptotic caspase-4 protects cells from PI-induced cell death. |
| 3 | 18006837 | The underlying mechanism of this antitumor effect involves the potent stimulation of the endoplasmic reticulum (ER) stress response (ESR), as indicated by increased expression of two ESR markers, GRP78 and CHOP, and activation of ESR-associated caspase-4. |
| 4 | 18006837 | Induction of ESR seems to play a central role in PI-induced cell death because small interfering RNA-mediated knockdown of the protective ER chaperone GRP78 sensitizes cells; whereas knockdown of proapoptotic caspase-4 protects cells from PI-induced cell death. |