- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: CASP6
Gene name: caspase 6, apoptosis-related cysteine peptidase
HGNC ID: 1507
Synonyms: MCH2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15746249 | Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. |
| 2 | 15746249 | TNF-alpha is a mediator of insulin resistance in sepsis, obesity, and type 2 diabetes and is known to impair insulin signaling in adipocytes. |
| 3 | 15746249 | In the present study we examined the posttranslational mechanisms by which short-term (<6-h) exposure of 3T3-L1 adipocytes to TNF-alpha decreases Akt levels. |
| 4 | 15746249 | TNF-alpha treatment both increased the ubiquitination of Akt and decreased its protein level. |
| 5 | 15746249 | The decrease in protein was associated with the presence of an (immunoreactive) Akt fragment after TNF-alpha treatment, indicative of Akt cleavage. |
| 6 | 15746249 | The caspase-6 inhibitor Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH(2)F potently suppressed Akt ubiquitination, degradation, and fragment formation, whereas the proteasome inhibitor Z-Leu-Leu-Leu-CHO modestly attenuated the decline in Akt levels. |
| 7 | 15746249 | Exposure to TNF-alpha also enhanced the association of Akt with an E3 ligase activity. |
| 8 | 15746249 | Adipocytes preexposed to TNF-alpha for 5 h and then stimulated with insulin for 30 min exhibited decreased levels of Akt, phosphorylated Akt, as well as phosphorylated Mdm2, which is a known direct substrate of Akt, and glucose uptake. |
| 9 | 15746249 | Collectively, our results suggest that TNF-alpha induces the caspase-dependent degradation of Akt via the cleavage and ubiquitination of Akt, which results in its degradation through the 26S proteasome. |
| 10 | 15746249 | Furthermore, the caspase- and proteasome-mediated degradation of Akt due to TNF-alpha exposure leads to impaired Akt-dependent insulin signaling in adipocytes. |
| 11 | 15746249 | These findings expand the mechanism by which TNF-alpha impairs insulin signaling. |