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Gene Information
Gene symbol: CASP7
Gene name: caspase 7, apoptosis-related cysteine peptidase
HGNC ID: 1508
Synonyms: MCH3, CMH-1, ICE-LAP3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | BAX | 1 hits |
| 3 | BCL2 | 1 hits |
| 4 | BIRC5 | 1 hits |
| 5 | CASP14 | 1 hits |
| 6 | CASP2 | 1 hits |
| 7 | CASP3 | 1 hits |
| 8 | CASP8 | 1 hits |
| 9 | CCND1 | 1 hits |
| 10 | IAPP | 1 hits |
| 11 | IDDM2 | 1 hits |
| 12 | JUP | 1 hits |
| 13 | MAPK1 | 1 hits |
| 14 | PARP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12164482 | PARP is activated at an intermediate stage of apoptosis and is then cleaved and inactivated at a late stage by apoptotic proteases, namely caspase-3/CPP-32/Yama/apopain and caspase-7. |
| 2 | 14679087 | Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family. |
| 3 | 14679087 | Caspase 7 (CASP7), an apoptosis-related cysteine protease, is one of the few known genes in this region. |
| 4 | 14679087 | Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family. |
| 5 | 14679087 | Caspase 7 (CASP7), an apoptosis-related cysteine protease, is one of the few known genes in this region. |
| 6 | 14708732 | The inhibitor of apoptosis protein (IAP) Survivin has an anti-apoptotic function mediated by several mechanisms; these include inhibiting caspase 3 and caspase 7. |
| 7 | 17196791 | The MAP family kinases, including ERK and p38 kinase, and the transcription factor c-Jun were all activated by phosphorylation after 1 h exposure to acrolein. |
| 8 | 17196791 | Thus, blockade of ERK and p38 inhibited chromatin condensation, caspase-7 and -9 activation as well as ICAD cleavage induced by acrolein. |
| 9 | 17196791 | JNK and AKT kinases seem to be implicated in survival pathways against acrolein insult, since their respective inhibitors, SP600125 and LY294002/Wortmannin switched the mode of cell death from apoptosis to total necrosis. |
| 10 | 17196791 | Finally, acrolein induced phosphorylation of the pro-apoptotic factor p53 which is responsible for transcription of pro-apoptotic factors such as Bax and Fas ligand. |
| 11 | 17196791 | These results provide new information demonstrating the implication of MAPKs and AKT in acrolein-induced apoptosis, and this information may be useful for understanding the pathogenesis of a number of tissue diseases and environmental toxicity in response to acrolein. |
| 12 | 23054864 | The results showed breast cancer cells respond in a diverse manner to LiCl, i.e., at lower concentrations (1, 5, and 10 mM), LiCl induces cell survival by inhibiting apoptosis through regulation of GSK-3β, caspase-2, Bax, and cleaved caspase-7 and by activating anti-apoptotic proteins (Akt, β-catenin, Bcl-2, and cyclin D1). |