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Gene Information
Gene symbol: CCDC22
Gene name: coiled-coil domain containing 22
HGNC ID: 28909
Synonyms: JM1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXP3 | 1 hits |
| 2 | PTPRN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11937581 | The related tyrosine phosphatase-like proteins islet Ag (IA)-2 and IA-2beta are autoantigens of type 1 diabetes in humans. |
| 2 | 11937581 | We used the close homology of IA-2 and IA-2beta to design chimeras and mutants to identify humoral IA-2-specific epitopes. |
| 3 | 11937581 | Two major IA-2 epitopes that are absent from the related autoantigens IA-2beta and IA-2Delta 13 splice variant ICA512.bdc were found contiguous to each other within IA-2 juxtamembrane amino acids 611-620 (epitope JM1) and 621-630 (epitope JM2). |
| 4 | 11937581 | JM1 and JM2 are recognized by sera from 67% of patients with IA-2 Abs, and relatives of patients with type 1 diabetes having Abs to either JM epitope had a >50% risk for developing type 1 diabetes within 6 years, even in the absence of diabetes-associated HLA genotypes. |