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Gene Information
Gene symbol: CDH1
Gene name: cadherin 1, type 1, E-cadherin (epithelial)
HGNC ID: 1748
Synonyms: uvomorulin, CD324
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APC | 1 hits |
| 2 | CAD | 1 hits |
| 3 | CDC20 | 1 hits |
| 4 | CDC27 | 1 hits |
| 5 | CDH17 | 1 hits |
| 6 | GNA12 | 1 hits |
| 7 | HNF4A | 1 hits |
| 8 | LAMB1 | 1 hits |
| 9 | SIRT2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8187462 | Risk factors for ECAD and CAD should be treated in patients with ECAD. |
| 2 | 11553328 | An essential aspect of progression through mitosis is the sequential degradation of key mitotic regulators in a process that is mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase [1]. |
| 3 | 11553328 | In mitotic cells, two forms of the APC/C exist, APC/C(Cdc20) and APC/C(Cdh1), which differ in their associated WD-repeat proteins (Cdc20 and Cdh1, respectively), time of activation, and substrate specificity [2, 3]. |
| 4 | 11553328 | One such APC/C substrate, the budding yeast anaphase inhibitor Pds1 (securin), is degraded prior to anaphase initiation in a destruction box and APC/C(Cdc20)-dependent manner [3, 7]. |
| 5 | 20862307 | Expression of cadherin 1, a component of the adherens junction adhesion complex, was maintained in these tumors despite the genetic deletion of desmoplakin. |
| 6 | 21300624 | Amongst these are multiple genes involved in IL23/Th17 signalling (IL23R, IL12B, JAK2, TYK2 and STAT3), IL10, IL1R2, REL, CARD9, NKX2.3, ICOSLG, PRDM1, SMAD3 and ORMDL3. |
| 7 | 21300624 | For Crohn's disease, defective processing of intracellular bacteria has become a central theme, following gene discoveries in autophagy and innate immunity (associations with NOD2, IRGM, ATG16L1 are specific to Crohn's disease). |
| 8 | 21300624 | Genetic evidence has also demonstrated the importance of barrier function to the development of ulcerative colitis (HNF4A, LAMB1, CDH1 and GNA12). |
| 9 | 22014574 | SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. |
| 10 | 22014574 | We demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20. |
| 11 | 22014574 | SIRT2 deficiency caused increased levels of mitotic regulators, including Aurora-A and -B that direct centrosome amplification, aneuploidy, and mitotic cell death. |