Ignet

Gene Information

Gene symbol: CFH

Gene name: complement factor H

HGNC ID: 4883

Synonyms: HUS, FHL1, ARMS1

Related Genes

#	Gene Symbol	Number of hits
1	ACTN4	1 hits
2	AMDP1	1 hits
3	APOB	1 hits
4	APOE	1 hits
5	ARMS2	1 hits
6	C4BPA	1 hits
7	CALCRL	1 hits
8	CAST	1 hits
9	CFB	1 hits
10	CILP	1 hits
11	CLCNKB	1 hits
12	CRP	1 hits
13	CTNS	1 hits
14	GHR	1 hits
15	GPR182	1 hits
16	GYS1	1 hits
17	HMOX1	1 hits
18	HRG	1 hits
19	HTRA1	1 hits
20	IKBKAP	1 hits
21	INS	1 hits
22	KCNJ11	1 hits
23	LIPC	1 hits
24	LPAL2	1 hits
25	LPL	1 hits
26	ORM2	1 hits
27	P2RY2	1 hits
28	PON2	1 hits
29	SLC4A1	1 hits
30	TLR4	1 hits
31	TRH	1 hits
32	VTN	1 hits
33	VWF	1 hits

Related Sentences

#	PMID	Sentence
1	2265390	Recurrence of disease is a common histologic finding in many transplant recipients but, except for a few diseases such as HUS, FSGS, and oxalosis, it usually does not lead to graft failure.
2	12667633	The AM receptor, a complex formed by calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs), and the recently discovered AM-binding protein, complement factor H (fH), are expressed in the insulin-producing beta-cells.
3	14730686	One of the major difficulties in mining low abundance biomarkers from serum or plasma is due to the fact that a small number of proteins such as albumin, alpha2-macroglobulin, transferrin, and immunoglobulins, may represent as much as 80% of the total serum protein.
4	14730686	For example, haptoglobin and hemoglobin are elevated in sera of AD, IR/D2, and CHF patients.
5	14730686	The levels of several other proteins including fibrinogen and its fragments, alpha 2-macroglobulin, transthyretin, pro-platelet basic protein, protease inhibitors clade A and C, as well as proteins involved in the classical complement pathway such as complement C3, C4, and C1 inhibitor, were found to differ between IR/D2 and control sera.
6	14730686	The sera levels of proteins, such as the 10 kDa subunit of vitronectin, alpha 1-acid glycoprotein, apolipoprotein B100, fragment of factor H, and histidine-rich glycoprotein were observed to be different between AD and controls.
7	15705804	No significant differences were detected in the circulating insulin concentrations in the neonates, although beta-cell volume and numbers were reduced in HF1-3 neonates. beta-cell numbers also declined in HF1 and HF3 neonates. alpha-cell volume, number and size were, however, increased in HF1-3 neonates. alpha-cell size was also increased in HF1 and HF3 neonates.
8	16936080	Analysis of CFH, TLR4, and APOE polymorphism in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration.
9	17137217	Analyses of covariance adjusting for age, body mass index, hyperlipidemia, diabetes, smoking, drinking, and antihypertensive medication revealed that 17 polymorphisms in 16 genes (APOB, CAST, CLCNKB, CTNS, GHR, GYS1, HF1, IKBKAP, KCNJ11, LIPC, LPL, P2RY2, PON2, SLC4A1, TRH, VWF) were significantly associated with blood pressure variations.
10	17137217	Multivariate logistic regression analysis with adjustment for the same factors revealed that 11 polymorphisms in 11 genes (CAST, CTLA4, F5, GC, GHR, LIPC, PLA2G7, SLC4A1, SLCI8A1, TRH, VWF) showed significant associations with hypertension.
11	17137217	Five polymorphisms in five genes, CAST(calpastatin), LIPC (hepatic lipase), SLC4A1 (band 3 anion transporter), TRH (thyrotropin-releasing hormone), and VWF (von Willebrand factor), were significantly associated with both blood pressure variation and hypertension.
12	17472578	The common Y402H variant in the CFH gene was not associated with classical cardiovascular risk factors (diabetes, hypercholesterolaemia, hypertension, obesity, smoking and C-reactive protein serum levels).
13	18704199	Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.
14	19197355	By using an additive model of the CFH, LOC387715, and C2 variants, the odds ratios are 2.9, 3.4, and 0.4, with p-values of 10(-13), 10(-13), and 10(-3), respectively.
15	19833879	Complement factor H is expressed in adipose tissue in association with insulin resistance.
16	21947364	Validation experiments conducted for complement factor H, αB-crystallin, cartilage intermediate-layer protein, and heme oxygenase-1 show that the release and expression of these factors in adipocytes is regulated by differentiation and stimuli, which affect insulin sensitivity, as well as by obesity.
17	22155603	After controlling for established AMD risk factors, including polymorphisms of the genes encoding complement factor H (CFH) and age-related maculopathy susceptibility 2/HtrA serine peptidase (ARMS2/HTRA1), and smoking history, we found that ultraviolet irradiance was protective for the development of neovascular AMD (p = 0.001).
18	22155603	Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort.
19	22334700	Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.
20	22334700	Islet amyloid polypeptide (IAPP) is synthesized in pancreatic β-cells and co-secreted with insulin.
21	22334700	Furthermore, IAPP also bound complement inhibitors factor H and C4b-binding protein (C4BP).
22	22334700	Immunostaining of pancreatic sections from type 2 diabetic patients revealed the presence of complement factors in the islets and varying degree of co-localization between IAPP fibrils and C1q, C3d, as well as C4BP and factor H but not membrane attack complex.
23	22334700	Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.
24	22334700	Islet amyloid polypeptide (IAPP) is synthesized in pancreatic β-cells and co-secreted with insulin.
25	22334700	Furthermore, IAPP also bound complement inhibitors factor H and C4b-binding protein (C4BP).
26	22334700	Immunostaining of pancreatic sections from type 2 diabetic patients revealed the presence of complement factors in the islets and varying degree of co-localization between IAPP fibrils and C1q, C3d, as well as C4BP and factor H but not membrane attack complex.
27	23296223	[Role of CFH and ARMS2 polymorphisms in retinopathy and coronary artery disease in type 1 diabetes].
28	23864767	Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients.