Ignet

Gene Information

Gene symbol: CHGB

Gene name: chromogranin B (secretogranin 1)

HGNC ID: 1930

Related Genes

#	Gene Symbol	Number of hits
1	CARTPT	1 hits
2	CHGA	1 hits
3	EGR1	1 hits
4	GAP43	1 hits
5	HTR2B	1 hits
6	INS	1 hits
7	NEFM	1 hits
8	NPY	1 hits
9	PCLD	1 hits
10	PDX1	1 hits
11	SLIT2	1 hits

Related Sentences

#	PMID	Sentence
1	15125025	The immunohistochemical data showed that, among the established islet hormones, insulin was present in more than 50% of cells, whereas glucagon and somatostatin occurred only sporadically.
2	15125025	Though cells positive for pancreatic polypeptide (PP) were not found, PP-related peptides (NPY and PYY) however could be detected in a minority of cells.
3	15125025	The great majority of RINm5F cells were immunoreactive for chromogranin B (CgB), followed by insulin, chromogranin A (CgA), and serotonin (5-HT).
4	16497807	Semiquantitative RT-PCR confirmed the overexpression of four genes involved in neuroendocrine differentiation and neuronal plasticity (chromogranin B, growth-associated protein 43, neurofilament 3, and Slit2) in the adrenal glands of FR50 rats.
5	18437352	Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.
6	21898210	RT-PCR was performed on a range of mRNAs, including Pdx1, Npy, Egr1, Pld1, Chgb, InsI, InsII, and Actb in biological triplicate analyses.Reproducible amplification of these mRNAs from MIN6, MIN6 B1, and Vero-PPI cells and their CM suggests that beta cells transcribe and release these mRNAs into their environment. mRNAs secreted from insulin-producing cells into their extracellular environment may have potential as extracellular biomarkers for assessing beta cell mass and function.
7	23939195	The biochemical utility of chromogranin A, chromogranin B and cocaine- and amphetamine-regulated transcript for neuroendocrine neoplasia.
8	23939195	The peptides chromogranin A (CgA), chromogranin B (CgB) and cocaine- and amphetamine-regulated transcript (CART) are widely distributed throughout the neuroendocrine system.
9	23939195	CgA and CgB have been used as general NEN biomarkers for many years, while CART has only recently been identified.
10	23939195	However, circulating CgA concentrations exhibit considerable intra-individual biological variation, are altered by proton pump inhibitors (PPIs) and somatostatin analogues and are elevated in non-NEN malignancies.
11	23939195	The effects of treatment and non-NEN conditions on circulating CgB and CART concentrations are less well understood.
12	23939195	CgB is less affected by impaired renal function and PPIs than CgA; while, circulating CART concentrations lack a diurnal variation in humans and are more reliable markers of pancreatic NEN malignancy than CgA.
13	23939195	However, the utility of CgB and CART in NEN management is yet to be elucidated.
14	23939195	Further studies are needed to establish whether CgB and CART are useful alternatives to CgA.
15	23939195	The biochemical utility of chromogranin A, chromogranin B and cocaine- and amphetamine-regulated transcript for neuroendocrine neoplasia.
16	23939195	The peptides chromogranin A (CgA), chromogranin B (CgB) and cocaine- and amphetamine-regulated transcript (CART) are widely distributed throughout the neuroendocrine system.
17	23939195	CgA and CgB have been used as general NEN biomarkers for many years, while CART has only recently been identified.
18	23939195	However, circulating CgA concentrations exhibit considerable intra-individual biological variation, are altered by proton pump inhibitors (PPIs) and somatostatin analogues and are elevated in non-NEN malignancies.
19	23939195	The effects of treatment and non-NEN conditions on circulating CgB and CART concentrations are less well understood.
20	23939195	CgB is less affected by impaired renal function and PPIs than CgA; while, circulating CART concentrations lack a diurnal variation in humans and are more reliable markers of pancreatic NEN malignancy than CgA.
21	23939195	However, the utility of CgB and CART in NEN management is yet to be elucidated.
22	23939195	Further studies are needed to establish whether CgB and CART are useful alternatives to CgA.