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Gene Information
Gene symbol: CHST3
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CTRB1 | 1 hits |
| 2 | DPP4 | 1 hits |
| 3 | GCG | 1 hits |
| 4 | INS | 1 hits |
| 5 | TMEM114 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23674605 | GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. |
| 2 | 23674605 | Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P ≤ 8.8 × 10(-7)). rs7202877 near CTRB1/2, a known diabetes risk locus, also associated with an absolute 0.51 ± 0.16% (5.6 ± 1.7 mmol/mol) lower A1C response to DPP-4 inhibitor treatment in G-allele carriers, but there was no effect on GLP-1 RA treatment in type 2 diabetic patients (n = 527). |
| 3 | 23674605 | Furthermore, in pancreatic tissue, we show that rs7202877 acts as expression quantitative trait locus for CTRB1 and CTRB2, encoding chymotrypsinogen, and increases fecal chymotrypsin activity in healthy carriers. |