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Gene Information
Gene symbol: CLCF1
Gene name: cardiotrophin-like cytokine factor 1
HGNC ID: 17412
Synonyms: NNT1, BSF3, CLC, NR6, CISS2, BSF-3, NNT-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CNTF | 1 hits |
| 2 | CNTFR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15542451 | CNTF mediates its function by activating a tripartite receptor comprising the CNTF receptor alpha chain (CNTFRalpha), the leukemia inhibitory factor receptor beta chain (LIFRbeta) and gp130. |
| 2 | 15542451 | Rat and human CNTF differ in their fine specificities: in addition to CNTFR, rat CNTF has been shown to activate the LIFR (a heterodimer of LIFRbeta and gp130), whereas human CNTF can bind and activate a tripartite receptor comprising the IL-6 receptor alpha chain (IL-6Ralpha) and LIFR. |
| 3 | 15542451 | Recombinant mouse CNTF was active and showed a high level of specificity for mouse CNTFR. |
| 4 | 15542451 | Recombinant mouse CNTF is therefore specific for CNTFR and as such represents a useful tool with which to study CNTF in mouse models. |
| 5 | 15542451 | It appears well suited for the comparative evaluation of CNTF and the two additional recently discovered CNTFR ligands, cardiotrophin-like cytokinecytokine-like factor-1 and neuropoietin. |