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Gene Information
Gene symbol: CLCN2
Gene name: chloride channel, voltage-sensitive 2
HGNC ID: 2020
Synonyms: CLC2, EJM6, ClC-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACCN2 | 1 hits |
| 2 | BRAP | 1 hits |
| 3 | BSND | 1 hits |
| 4 | CBS | 1 hits |
| 5 | CFTR | 1 hits |
| 6 | GRIK2 | 1 hits |
| 7 | IMPDH2 | 1 hits |
| 8 | KCNA3 | 1 hits |
| 9 | KCNA5 | 1 hits |
| 10 | KCND3 | 1 hits |
| 11 | KCNE1 | 1 hits |
| 12 | KCNJ1 | 1 hits |
| 13 | KCNQ1 | 1 hits |
| 14 | KCNQ4 | 1 hits |
| 15 | PRKAA1 | 1 hits |
| 16 | SCN5A | 1 hits |
| 17 | SGK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12176723 | Thus secretory granules of pancreatic acinar cell express a ClC-2 Cl(-) channel, a HCO-permeable member of the CLCA Ca(2+)-dependent anion channel family, and a KCNQ1 K(+) channel. |
| 2 | 14722619 | However, their importance was underlined by findings that mutations in conserved residues within them cause a variety of human hereditary diseases, including (with the gene mutated in parentheses): Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase); retinitis pigmentosa (IMP dehydrogenase-1); congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members); and homocystinuria (cystathionine beta-synthase). |
| 3 | 14722619 | We now show that tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine beta-synthase bind AMP, ATP, or S-adenosyl methionine,while mutations that cause hereditary diseases impair this binding. |
| 4 | 23012321 | SGK1 is activated by insulin and growth factors through PI3K and 3-phosphoinositide-dependent kinase PDK1. |
| 5 | 23012321 | SGK1 activates a wide variety of ion channels (e.g., ENaC, SCN5A, TRPV4-6, ROMK, Kv1.3, Kv1.5, Kv4.3, KCNE1/KCNQ1, KCNQ4, ASIC1, GluR6, ClCKa/barttin, ClC2, CFTR, and Orai/STIM), which participate in the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation, and apoptosis. |