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Gene Information

Gene symbol: CLN3

Gene name: ceroid-lipofuscinosis, neuronal 3

HGNC ID: 2074

Synonyms: JNCL

Related Genes

#	Gene Symbol	Number of hits
1	GAD2	1 hits
2	TPP1	1 hits

Related Sentences

#	PMID	Sentence
1	16972881	Autoantibodies to glutamic acid decarboxylase (GAD65) have been reported in sera from the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis (JNCL), and in individuals with this fatal paediatric neurodegenerative disorder.
2	16972881	To investigate the existence of other circulating autoreactive antibodies, we used sera from patients with JNCL and other forms of neuronal ceroid lipofuscinosis (NCL) as primary antisera to stain rat and human central nervous system sections.
3	16972881	JNCL sera displayed characteristic patterns of IgG, but not IgA, IgE or IgM immunoreactivity that was distinct from the other forms of NCL.
4	16972881	Moreover, sera from Stiff Person Syndrome and Type I Diabetes, disorders in which GAD65 autoantibodies are present, stained with profiles that were markedly different from JNCL sera.
5	16972881	Collectively, these studies provide evidence of the presence of autoreactive antibodies within multiple forms of NCL, and are not exclusively directed towards GAD65.