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Gene Information
Gene symbol: CLS
Gene name: Coffin-Lowry syndrome
HGNC ID: 2089
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MIP | 1 hits |
| 2 | RPS6KA3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11113183 | The p90 ribosomal S6 kinase (RSK), a cytosolic substrate for the extracellular signal-regulated kinase (ERK), is involved in transcriptional regulation, and one isoform (RSK2) has been implicated in the activation of glycogen synthase by insulin. |
| 2 | 11113183 | To determine RSK2 function in vivo, mice lacking a functional rsk2 gene were generated and studied in response to insulin and exercise, two potent stimulators of the ERK cascade in skeletal muscle. |
| 3 | 11113183 | While insulin and exercise significantly increased ERK phosphorylation in skeletal muscle from both WT and KO mice, the increases were twofold greater in the KO animals. |
| 4 | 11113183 | The enhanced insulin-stimulated increases in ERK and glycogen synthase activities in KO mice were not associated with higher insulin receptor or with IRS1 tyrosine phosphorylation or with IRS1 binding to phosphatidylinositol 3-kinase. |
| 5 | 11113183 | However, insulin-stimulated serine phosphorylation of Akt was significantly higher in the KO animals. c-fos mRNA was increased similarly in muscle from WT and KO mice in response to insulin (2. 5-fold) and exercise (15-fold). |
| 6 | 11113183 | In conclusion, RSK2 likely plays a major role in feedback inhibition of the ERK pathway in skeletal muscle. |
| 7 | 11113183 | Furthermore, RSK2 is not required for activation of muscle glycogen synthase by insulin but may indirectly modulate muscle glycogen synthase activity and/or glycogen content by other mechanisms, possibly through regulation of Akt. |
| 8 | 11113183 | RSK2 knockout mice may be a good animal model for the study of Coffin-Lowry syndrome. |
| 9 | 16749244 | CLS meets the aquaporin family: clinical cases involving aquaporin systems. |
| 10 | 16749244 | For example, the flow rate of water through AQP1 is an extraordinary three billion water molecules per second per aquaporin channel, while a relative trickle of water crosses the hydrophobic lipid bilayer of cell membranes devoid of AQPs. |