Ignet

Gene Information

Gene symbol: CLTC

Gene name: clathrin, heavy chain (Hc)

HGNC ID: 2092

Synonyms: Hc

Related Genes

#	Gene Symbol	Number of hits
1	CLTCL1	1 hits
2	PRKCA	1 hits
3	PRKCD	1 hits
4	PRKCZ	1 hits
5	SLC2A4	1 hits

Related Sentences

#	PMID	Sentence
1	17210758	N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro.
2	17210758	This study aimed to evaluate the effect of alpha-cyano-4-hydroxycinnamic acid (CHC) and N-acetylcysteine (NAC) addition on morphology and activity of protein kinase C-delta and protein kinase C-zeta in rat embryos exposed to a high glucose concentration in vitro.
3	17210758	Day 9 embryos from normal rats were cultured in 10 or 30 mM glucose concentrations with or without supplementation of CHC, NAC, or protein kinase C inhibitors specific for protein kinase C-delta and protein kinase C-zeta.
4	17210758	Protein kinase C-delta and protein kinase C-zeta activities were estimated by western blot by separating membranous and cytosolic fractions of the embryo.
5	17210758	These abnormalities were diminished when CHC and NAC or specific protein kinase C-inhibitors were added to the culture medium.
6	17210758	The activities of embryonic protein kinase C-delta and protein kinase C-zeta were increased in the high glucose environment after 24-h culture, but were normalized by the addition of CHC and NAC as well as respective inhibitor to the culture medium.
7	17210758	Furthermore, such overproduction may affect embryonic development, at least partly, by enhancing the activities of protein kinase C-delta and protein kinase C-zeta.
8	17210758	N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro.
9	17210758	This study aimed to evaluate the effect of alpha-cyano-4-hydroxycinnamic acid (CHC) and N-acetylcysteine (NAC) addition on morphology and activity of protein kinase C-delta and protein kinase C-zeta in rat embryos exposed to a high glucose concentration in vitro.
10	17210758	Day 9 embryos from normal rats were cultured in 10 or 30 mM glucose concentrations with or without supplementation of CHC, NAC, or protein kinase C inhibitors specific for protein kinase C-delta and protein kinase C-zeta.
11	17210758	Protein kinase C-delta and protein kinase C-zeta activities were estimated by western blot by separating membranous and cytosolic fractions of the embryo.
12	17210758	These abnormalities were diminished when CHC and NAC or specific protein kinase C-inhibitors were added to the culture medium.
13	17210758	The activities of embryonic protein kinase C-delta and protein kinase C-zeta were increased in the high glucose environment after 24-h culture, but were normalized by the addition of CHC and NAC as well as respective inhibitor to the culture medium.
14	17210758	Furthermore, such overproduction may affect embryonic development, at least partly, by enhancing the activities of protein kinase C-delta and protein kinase C-zeta.
15	17210758	N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro.
16	17210758	This study aimed to evaluate the effect of alpha-cyano-4-hydroxycinnamic acid (CHC) and N-acetylcysteine (NAC) addition on morphology and activity of protein kinase C-delta and protein kinase C-zeta in rat embryos exposed to a high glucose concentration in vitro.
17	17210758	Day 9 embryos from normal rats were cultured in 10 or 30 mM glucose concentrations with or without supplementation of CHC, NAC, or protein kinase C inhibitors specific for protein kinase C-delta and protein kinase C-zeta.
18	17210758	Protein kinase C-delta and protein kinase C-zeta activities were estimated by western blot by separating membranous and cytosolic fractions of the embryo.
19	17210758	These abnormalities were diminished when CHC and NAC or specific protein kinase C-inhibitors were added to the culture medium.
20	17210758	The activities of embryonic protein kinase C-delta and protein kinase C-zeta were increased in the high glucose environment after 24-h culture, but were normalized by the addition of CHC and NAC as well as respective inhibitor to the culture medium.
21	17210758	Furthermore, such overproduction may affect embryonic development, at least partly, by enhancing the activities of protein kinase C-delta and protein kinase C-zeta.
22	19478182	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
23	19478182	Clathrin is involved in intracellular trafficking, and in humans, the clathrin heavy-chain isoform CHC22 is highly expressed in skeletal muscle.
24	19478182	We found a role for CHC22 in the formation of insulin-responsive GLUT4 compartments in human muscle and adipocytes.
25	19478182	CHC22 also associated with expanded GLUT4 compartments in muscle from type 2 diabetic patients.
26	19478182	Tissue-specific introduction of CHC22 in mice, which have only a pseudogene for this protein, caused aberrant localization of GLUT4 transport pathway components in their muscle, as well as features of diabetes.
27	19478182	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
28	19478182	Clathrin is involved in intracellular trafficking, and in humans, the clathrin heavy-chain isoform CHC22 is highly expressed in skeletal muscle.
29	19478182	We found a role for CHC22 in the formation of insulin-responsive GLUT4 compartments in human muscle and adipocytes.
30	19478182	CHC22 also associated with expanded GLUT4 compartments in muscle from type 2 diabetic patients.
31	19478182	Tissue-specific introduction of CHC22 in mice, which have only a pseudogene for this protein, caused aberrant localization of GLUT4 transport pathway components in their muscle, as well as features of diabetes.
32	20132771	[The CHC22 human clathrin heavy chain isoform, intracellular traffic of the glucose transporter GLUT4, and type 2 diabetes].