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PMID |
Sentence |
1 |
12438247
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Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype.
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2 |
12438247
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Several lines of evidence support an important role for the insulin-like growth factor system in breast cancer.
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3 |
12438247
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Alterations in insulin-like growth factor I receptor (IGF-IR) have been associated with breast cancer metastasis; however, the specific role played by the IGF-IR in this process remains unclear.
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4 |
12438247
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Moreover, there was a significant reduction in p120 present in the E-cadherin-catenin-p120 complex.
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5 |
12438247
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There was a 2-fold increase in active Rac1 and Cdc42 and a 35% decrease in active Rho in the SX13 cells.
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6 |
12438247
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Our findings strongly suggest that the IGF-IR plays a role in the stabilization of the E-cadherin-catenin complex, thereby providing one possible explanation for the association between low levels of IGF-IR and a higher risk of mammary tumor metastasis.
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7 |
23337773
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These AJ structures are maintained by E-cadherin and catenin complexes such as β-catenin and p120 catenin.
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8 |
23337773
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In the diabetic state, enhanced Rho and Rho-kinase activity reduced p120 catenin expression and altered the distribution of p120 catenin and E-cadherin, which are normally localized in the paranodal compartment of the nodes of Ranvier and Schmidt-Lanterman incisures where autotypic AJs stabilize myelin structure.
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9 |
23337773
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Fasudil restored normal p120 catenin expression and the distribution of p120 catenin and E-cadherin in the myelin sheath.
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10 |
23337773
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These AJ structures are maintained by E-cadherin and catenin complexes such as β-catenin and p120 catenin.
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11 |
23337773
|
In the diabetic state, enhanced Rho and Rho-kinase activity reduced p120 catenin expression and altered the distribution of p120 catenin and E-cadherin, which are normally localized in the paranodal compartment of the nodes of Ranvier and Schmidt-Lanterman incisures where autotypic AJs stabilize myelin structure.
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12 |
23337773
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Fasudil restored normal p120 catenin expression and the distribution of p120 catenin and E-cadherin in the myelin sheath.
|
13 |
23337773
|
These AJ structures are maintained by E-cadherin and catenin complexes such as β-catenin and p120 catenin.
|
14 |
23337773
|
In the diabetic state, enhanced Rho and Rho-kinase activity reduced p120 catenin expression and altered the distribution of p120 catenin and E-cadherin, which are normally localized in the paranodal compartment of the nodes of Ranvier and Schmidt-Lanterman incisures where autotypic AJs stabilize myelin structure.
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15 |
23337773
|
Fasudil restored normal p120 catenin expression and the distribution of p120 catenin and E-cadherin in the myelin sheath.
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