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Gene Information
Gene symbol: CTRB2
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C14orf181 | 1 hits |
| 2 | C19orf10 | 1 hits |
| 3 | C6orf173 | 1 hits |
| 4 | CD69 | 1 hits |
| 5 | CLEC16A | 1 hits |
| 6 | CTLA4 | 1 hits |
| 7 | CTRB1 | 1 hits |
| 8 | CTSH | 1 hits |
| 9 | ERBB3 | 1 hits |
| 10 | IFIH1 | 1 hits |
| 11 | INS | 1 hits |
| 12 | ITPR3 | 1 hits |
| 13 | PTPN22 | 1 hits |
| 14 | SH2B3 | 1 hits |
| 15 | SIRPG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21270831 | Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association. |
| 2 | 23674605 | GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. |
| 3 | 23674605 | Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P ≤ 8.8 × 10(-7)). rs7202877 near CTRB1/2, a known diabetes risk locus, also associated with an absolute 0.51 ± 0.16% (5.6 ± 1.7 mmol/mol) lower A1C response to DPP-4 inhibitor treatment in G-allele carriers, but there was no effect on GLP-1 RA treatment in type 2 diabetic patients (n = 527). |
| 4 | 23674605 | Furthermore, in pancreatic tissue, we show that rs7202877 acts as expression quantitative trait locus for CTRB1 and CTRB2, encoding chymotrypsinogen, and increases fecal chymotrypsin activity in healthy carriers. |